International Journal Of Bilogical Sciences
.: Home > International Journal Of Bilogical Sciences > 2012 > Volume 8 Number 9 > Maximilian J. Waldner, Sebastian Foersch, Markus F. Neurath✉
Interleukin-6 - A Key Regulator of Colorectal Cancer Development
Maximilian J. Waldner, Sebastian Foersch, Markus F. Neurath✉
Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany.
Growing evidence proposes an important role for pro-inflammatory cytokines during tumor development. Several experimental and clinical studies have linked the pleiotropic cytokine interleukin-6 (IL-6) to the pathogenesis of sporadic and inflammation-associated colorectal cancer (CRC). Increased IL-6 expression has been related to advanced stage of disease and decreased survival in CRC patients. According to experimental studies, these effects are mediated through IL-6 trans-signaling promoting tumor cell proliferation and inhibiting apoptosis through gp130 activation on tumor cells with subsequent signaling through Janus kinases (JAKs) and signal transducer and activator of transcription 3 (STAT3).
During recent years, several therapeutics targeting the IL-6/STAT3 pathway have been developed and pose a promising strategy for the treatment of CRC. This review discusses the molecular mechanisms and possible therapeutic targets involved in IL-6 signaling in CRC.
interleukin-6, IL-6, colorectal cancer
Date Deposited : 09 Apr 2015 14:36
Official URL: http://www.ijbs.com/ms/archive
Last Modified : 09 Apr 2015 14:36
Volume 8, Number 9, - 2012 , ISSN 1545-1003
Full Text Original