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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2011 > Volume 60 Number 2 > Tomoe FUKUMURA1)2), Hiroyuki KOSE1)3), Chiyo TAKEDA2), Yuko KURITA2), Kazuhiko OCHIAI1), Takahisa YAMADA4) and Kozo MATSUMOTO1)5)

Genetic Interaction between Hyperglycemic QTLs Is Manifested under a High Calorie Diet in OLETF-Derived Congenic Rats

Tomoe FUKUMURA1)2), Hiroyuki KOSE1)3), Chiyo TAKEDA2), Yuko KURITA2), Kazuhiko OCHIAI1), Takahisa YAMADA4) and Kozo MATSUMOTO1)5)
1) Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima Graduate School 2) Graduate School of Human Life Science, Osaka City University 3) Department of Life Science, Division of Natural Sciences, International Christian University 4) Laboratory of Animal Genetics, Graduate School of Science and Technology, Niigata University 5) Department of Animal Medical Sciences, Faculty of Life Sciences, Kyoto Sangyo University
Abstract :

The condition of hyperglycemia results from multiple genetic and environmental factors. In recent years much progress has been made with regards to the search for candidate genes involved in the expression of various common diseases including type 2 diabetes. However less is known about the specific genetic and environmental connections that are important for the development of the disease. In the present study, we used hyperglycemic congenic rats to address this issue. When given a normal diet, two hyperglycemic QTLs (quantitative trait locus), Nidd2/of and Nidd10/of, showed mild obesity and/or increased blood glucose in the oral glucose tolerance test. In a double congenic strain possessing both loci, these indices were not significantly different from those of either single congenic strain. In contrast, the double congenic strain fed a high-calorie diet showed significantly greater body weight than the single congenic strains or normoglycemic control rats. Although postprandial glucose levels of the double congenic rat were not further aggravated even on the high fat diet, it was notable that the postprandial insulin levels were drastically elevated. From these results, we constructed a novel model animal especially for the study of prediabetic hyperinsulemia, in which two QTLs and an additional dietary condition are involved. This may help to shed light on the genetic basis and gene-to-diet interaction during the early stage of type 2 diabetes.

Keywords :
congenic rat, epistasis, QTL, type 2 diabetes

Date Deposited : 21 Jun 2011 11:38

Last Modified : 21 Jun 2011 11:38

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Volume 60, Number 2, - 2011

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