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.: Home > Animal Bioresource in Japan > 2011 > Volume 60 Number 2 > Youn-Hwan HWANG1) and Hyo-In YUN1)2)

Effects of Acute Hepatic and Renal Failure on Pharmacokinetics of Flunixin Meglumine in Rats

Youn-Hwan HWANG1) and Hyo-In YUN1)2)
1) Institute of Veterinary Science, Chungnam National University 2) Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University
Abstract :

The aim of this study was to investigate the effects of hepatic and renal failure on the pharmacokinetics of flunixin in carbon tetrachloride (CCl4)- and glycerol-treated rats. After intravenous administration of flunixin (2 mg/kg), the plasma concentration of flunixin was measured by high-performance liquid chromatography. Both acute hepatic and renal failure resulted in significantly increased area under the curve (AUC), prolonged elimination half-life (t1/2β), and reduced total body clearance (Cltot) compared with respective controls (P<0.05). In conclusion, hepatic failure as well as renal failure modified the pharmacokinetics of flunixin.

Keywords :
acute renal and hepatic failure, flunixin, pharmacokinetics

Date Deposited : 21 Jun 2011 12:36

Last Modified : 21 Jun 2011 12:36

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Volume 60, Number 2, - 2011

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