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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2010 > Volume 59 Number 1 > Yukihito ISHII1), Takeshi OHTA1), Tomohiko SASASE1), Hisayo MORINAGA1), Nobuhisa UEDA1), Takahiro HATA1), Makoto KAKUTANI1), Katsuhiro MIYAJIMA2), Yoshiaki KATSUDA1), Taku MASUYAMA2), Masami SHINOHARA3) and Mutsuyoshi MATSUSHITA1)

Pathophysiological Analysis of Female Spontaneously Diabetic Torii Fatty Rats

Yukihito ISHII1), Takeshi OHTA1), Tomohiko SASASE1), Hisayo MORINAGA1), Nobuhisa UEDA1), Takahiro HATA1), Makoto KAKUTANI1), Katsuhiro MIYAJIMA2), Yoshiaki KATSUDA1), Taku MASUYAMA2), Masami SHINOHARA3) and Mutsuyoshi MATSUSHITA1)
1) Central Pharmaceutical Research Institute, Japan Tobacco Inc. 2) Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. 3) Planning and Development Section, CLEA Japan Inc.
Abstract :

Obesity, hyperglycemia, hyperlipidemia, and diabetes-associated complications appear at younger ages (6-8 weeks) in the male Spontaneously Diabetic Torii-Leprfa (SDT-fa/fa) rat than in the male original SDT (SDT-+/+) rat. However, the incidence and progression of diabetes mellitus and diabetic complications in the female SDT-fa/fa rat have not been reported in detail. In the present study, the pathophysiological features of the female SDT-fa/fa rat were examined, and compared with those of the female SDT-+/+ rat. Female SDT-fa/fa rats showed hyperphagia, obesity, hyperglycemia, and hyperlipidemia from 5 or 6 weeks of age, and hyperinsulinemia was observed from 5 to 12 weeks. Pathological changes pancreatic islets were observed from 8 weeks. Renal function parameters, such as urine volume and urinary protein, increased from 16 weeks, and pathological findings in the renal tubule, and cataracts were also observed from 16 weeks. Increases of visceral and subcutaneous fats were obvious during the observation period. In pair-feeding with SDT-+/+ rats, SDT-fa/fa rats showed improved hyperglycemia and hypertriglycemia, but hypercholesterolemia was not entirely improved during the study period. Female SDT-fa/fa rats showed diabetes mellitus and diabetes-associated complications at young ages, and fat accumulation was remarkable. Suppression of hyperphagia in SDT-fa/fa rats was effective at improving hyperglycemia and hypertriglycemia. In conclusion, the female SDT-fa/fa rat has the potential to become an important animal model of type 2 diabetes mellitus with obesity, especially for women, for which few models currently exist.

Keywords :
diabetes, diabetic complication, female, SDT-fa/fa rat, SDT-+/+ rat

Date Deposited : 21 Jun 2011 13:24

Last Modified : 21 Jun 2011 14:18

Official URL: http://www.jstage.jst.go.jp/browse/expanim/60/1/_contents

Volume 59, Number 1, - 2010

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