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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2011 > Volume 60 Number 1 > Atsushi TOHEI1), Motoaki UMEZU2), Takao KANAI3), Keiichiro YAMAGUCHI4), Akinori KOSAKU4), Hiroe KON1) and Motoo SHINODA1)

Pituitary-Adrenal Functions in a Hereditary Hypothyroid (rdw) Rat

Atsushi TOHEI1), Motoaki UMEZU2), Takao KANAI3), Keiichiro YAMAGUCHI4), Akinori KOSAKU4), Hiroe KON1) and Motoo SHINODA1)
1) Laboratory Animal Research Center, Dokkyo Medical University 2) Laboratory of Animal Endocrinology and Reproduction, Faculty of Agriculture, Utsunomiya University 3) Institute of Laboratory Animals, Tokyo Women's Medical University 4) Department of Pathology, Dokkyo Medical University Hospital
Abstract :

The rdw rat is a hereditary hypothyroid strain isolated from Wistar-Imamichi rats. In the present study, adrenocorticotropic hormone (ACTH) and corticosterone responses to restraint stress (120 min) were examined in rdw adult male rats. ACTH response to restraint stress was higher in rdw rats than in hetero control rats. The plasma concentrations of corticosterone were lower in rdw rats than in control rats during the first 30 min after the onset of stress. Both ACTH and corticosterone responses to restraint stress in rdw rats recovered to control levels after thyroxine (T4) replacement therapy. These results suggest that hereditary hypothyroidism causes adrenal dysfunction directly and that hypersecretion of ACTH is a result of reduced corticosterone in rdw rats.

Keywords :
ACTH, corticosterone, hypothyroid

Date Deposited : 21 Jun 2011 13:27

Last Modified : 21 Jun 2011 13:27

Official URL: http://www.jstage.jst.go.jp/browse/expanim/60/1/_contents

Volume 60, Number 1, - 2011

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