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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2010 > Volume 59 Number 1 > Hiroshi SHITARA1), Midori SHIMANUKI1)2), Jun-Ichi HAYASHI2) and Hiromichi YONEKAWA1)2)

Global Imaging of Mitochondrial Morphology in Tissues Using Transgenic Mice Expressing Mitochondrially Targeted Enhanced Green Fluorescent Protein

Hiroshi SHITARA1), Midori SHIMANUKI1)2), Jun-Ichi HAYASHI2) and Hiromichi YONEKAWA1)2)
1) Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical Science 2) Graduate School of Life and Environmental Sciences, University of Tsukuba
Abstract :

The most common approach to analyzing the static morphology of mitochondria involves staining by antibodies or fluorescent dyes specific for mitochondrial components. In this study, we present a new approach using transgenic (Tg) mice, mtGFP-Tg mice, which exclusively express EGFP in the mitochondrial matrix. This Tg strain enables the rapid and easy observation of mitochondria in many kinds of tissues of interest. Recently, many reports have indicated that mitochondrial abnormalities and disease phenotypes are closely associated. mtGFP-Tg mice will be very useful in demonstrating this association, via the use of hybrids of mtGFP-Tg mice and well-established model mice for human diseases.

Keywords :
EGFP, mitochondrial morphology, transgenic mice

Date Deposited : 21 Jun 2011 13:31

Last Modified : 21 Jun 2011 14:18

Official URL: http://www.jstage.jst.go.jp/browse/expanim/60/1/_contents

Volume 59, Number 1, - 2010

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