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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2010 > Volume 59 Number 2 > Nobutaka DOE1)2), Tsutomu TAKAHASHI3) and Mika KIRIYAMA1)

Behavioral Despair during a Water Maze Learning Task in Mice

Nobutaka DOE1)2), Tsutomu TAKAHASHI3) and Mika KIRIYAMA1)
1) Section of Behavioral Science, Kouiken Co., Ltd. 2) Laboratory of Neurogenesis and CNS Repair, Institute for Advanced Medical Sciences, Hyogo College of Medicine 3) Department of Integrated Psychological Science, School of Humanities, Kwansei Gakuin University
Abstract :

In the case of mice, when the difficulty of a water maze learning task is increased, some animals gradually cease to swim, abandon adaptive learning, and become immobile. We trained 99 male C57BL/6N mice in a pool containing a hidden platform. The pool was surrounded by white featureless walls, and almost all external cues were removed. On the eighth day of escape training, 36 inferior-learners exhibited behavioral despair. The predictive validity of the inferior-learners as a depression model was verified by testing their sensitivity to clinically efficacious antidepressants. The inferior-learners treated with a selective serotonin reuptake inhibitor (SSRI), fluvoxamine, or a serotonin noradrenaline reuptake inhibitor (SNRI), milnacipran, resumed swimming and adaptive learning. Because of facial similarities between inferior-learners and depressive patients and their sensitivity to antidepressant drugs, our experimental method is expected to be an effective tool in basic research on depression.

Keywords :
animal model of depression, antidepressant screening, behavioral despair, mice, water maze learning

Date Deposited : 21 Jun 2011 13:49

Last Modified : 21 Jun 2011 14:13

Official URL: http://www.jstage.jst.go.jp/browse/expanim/60/1/_contents

Volume 59, Number 2, - 2010

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