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International Journal of Poultry Science

.: Home > International Journal of Poultry Science > 2016 > Volume 14 Number 8 > N. Nuthalapati , N. Alugubelly , B. Felfoldi , I. Bodi , N. Fejszak , G.T. Pharr and I. Olah 1 1 2 3 3 1 3

Monoclonal Antibody EIV-E12 Recognizes a Glycoprotein Antigen, Which Differs from the B-Cell-Specific chB6 (Bu-1) Antigen

N. Nuthalapati , N. Alugubelly , B. Felfoldi , I. Bodi , N. Fejszak , G.T. Pharr and I. Olah 1 1 2 3 3 1 3
Department of Basic Sciences, College of Veterinary Medicine, Box 6100, 1 Mississippi State University, Mississippi State, MS 39762, USA Ceva-Phylaxia Zrt., 1107 Budapest, Szallas u. 7, Hungary 2 Department of Human Morphology and Developmental Biology, 3 Semmelweis University, 1094 Budapest, Tuzolto u. 58, Hungary
Abstract :

The antigen (s) recognized by the EIV-E12 monoclonal antibody (mAb) is first detected in the embryonic bursal mesenchyme on the precursor to the bursal secretory dendritic cell. Later in bursal embryonic development the prebursal stem cells which enter the developing follicle express the antigen recognized by mAb EIV-E12. The goal of this project is to characterize the antigen recognized by mAb EIVE12. In western blotting the deglycosylated bursal proteins showed reduced reactivity to mAb EIV-E12, indicating, that the EIV-E12 epitope of the antigen may consist of a carbohydrate group that is common to chicken B-cells. The EIV-E12 positive antigen is expressed by the plasma cells of terminal maturation of Bcells unlike the B-cell specific chB6 antigen. These differences in the expression patterns of EIV-E12 and chB6 positive antigens are confirmed by their different molecular weights of 200 and 65 kDa, respectively.

Keywords :
Bursal B-cell, monoclonal antibody EIV-E12, novel B-cell antigen

Date Deposited : 02 Jan 2016 11:49

Last Modified : 02 Jan 2016 11:49

Official URL:

Volume 14, Number 8, - 2016 , ISSN 1682-8356

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