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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2015 > Volume 64 Number 2 > Akimasa Seno1–3), Takumi Maruhashi1,2), Tomonori Kaifu1,2,4), Rikio Yabe1,2), Noriyuki Fujikado1), Guangyu Ma1), Tetsuro Ikarashi5), Shigeru Kakuta5), and Yoichiro Iwakura1–4,6)

Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor

Akimasa Seno1–3), Takumi Maruhashi1,2), Tomonori Kaifu1,2,4), Rikio Yabe1,2), Noriyuki Fujikado1), Guangyu Ma1), Tetsuro Ikarashi5), Shigeru Kakuta5), and Yoichiro Iwakura1–4,6)
1)Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan 2)Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda-shi, Chiba 278-0022, Japan 3)Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwashi, Chiba 277-0882, Japan 4)Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Kawaguchi-shi, Saitama 332-0012, Japan 5)Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan 6)Medical Mycology Research Center, Chiba University, Chuo-ku, Chiba 250-8673, Japan
Abstract :

Dendritic cell immunoreceptor (DCIR) is a C-type lectin receptor containing a carbohydrate recognition domain in its extracellular portion and an immunoreceptor tyrosine–based inhibitory motif, which transduces negative signals into cells, in its cytoplasmic portion. Previously, we showed that Dcir–/– mice spontaneously develop autoimmune diseases such as enthesitis and sialadenitis due to excess expansion of dendritic cells (DCs), suggesting that DCIR is critically important for the homeostasis of the immune system. In this report, we analyzed the role of DCIR in the development of experimental autoimmune encephalomyelitis (EAE), an autoimmune disease model for multiple sclerosis. We found that EAE was exacerbated in Dcir–/– mice associated with severe demyelination of the spinal cords. The number of infiltrated CD11c+ DCs and CD4+ T cells into spinal cords was increased in Dcir–/– mice. Recall proliferative response of lymph node cells was higher in Dcir–/– mice compared with wild-type mice. These observations suggest that DCIR is an important negative regulator of the immune system, and Dcir–/– mice should be useful for analyzing the roles of DCIR in an array of autoimmune diseases.

Keywords :
C-type lectin receptor, dendritic cell immunoreceptor, experimental autoimmune encephalomyelitis, multiple sclerosis

Date Deposited : 06 Jan 2016 11:22

Last Modified : 06 Jan 2016 11:22

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/64/2/_contents

Volume 64, Number 2, - 2015 , ISSN 101–108

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