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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2015 > Volume 64 Number 2 > Sara Oliván, Ana Cristina Calvo, Amaya Rando, María Jesús Muñoz, Pilar Zaragoza, and Rosario Osta

Comparative study of behavioural tests in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Sara Oliván, Ana Cristina Calvo, Amaya Rando, María Jesús Muñoz, Pilar Zaragoza, and Rosario Osta
LAGENBIO-I3A, Facultad de Veterinaria, IIS Aragón, Universidad de Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain
Abstract :

 In preclinical trials, a sensitive functional test is required to detect changes in the motor behaviour of the SOD1G93A mouse model of amyotrophic lateral sclerosis (ALS). We evaluated changes in body weight and motor impairment in behavioural tests, such as the rotarod, the hangingwire test and the treadmill, of transgenic and wild type mice. We found differences in detection of the onset of symptoms and progression of the disease between the different tests assessed. Moreover, the data showed significant gender differences in the motor behaviour of this mouse model. The rotarod and the hanging-wire test were more sensitive to detect early motor impairment. Moreover, the results suggested that the rotarod and hanging-wire became the most accurate tests rather than treadmill to characterise the ALS disease phenotype

Keywords :
Amyotrophic lateral sclerosis, hanging-wire test, rotarod, SOD1G93A mice, treadmill

Date Deposited : 06 Jan 2016 11:30

Last Modified : 06 Jan 2016 11:30

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/64/2/_contents

Volume 64, Number 2, - 2015 , ISSN 147–153

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