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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2010 > Volume 59 Number 2 > Maria Shirley HERBAS1) and Hiroshi SUZUKI1)

Vitamin C Deficiency Fails to Protect Mice from Malaria

Maria Shirley HERBAS1) and Hiroshi SUZUKI1)
1) Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
Abstract :

Nutritional deficiencies are frequent in malaria-endemic areas. It seems that micronutrient antioxidants play an important role in malaria parasite’s proliferation. Thus, the effect of vitamin C deficiency on malaria infection was examined in mice. When vitamin C deficient mice, L-gulono-γ-lactone oxidase gene knockout mice which are unable to synthesize ascorbic acid, were infected with a lethal dose of Plasmodium berghei NK65-infected red blood cells, the knockout mice showed similar parasitemia kinetics and survival rates as wild-type mice. The results indicate that deficiency of vitamin C might not affect the development of the malaria parasite in mice.

Keywords :
ree radical, malaria, vitamin C

Date Deposited : 21 Jun 2011 14:01

Last Modified : 21 Jun 2011 14:15

Official URL:

Volume 59, Number 2, - 2010

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