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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2015 > Volume 64 Number 3 > Marie-Chantal Giroux1), Pierre Hélie2), Patrick Burns3), and Pascal Vachon1, 4)

Anesthetic and pathological changes following high doses of ketamine and xylazine in Sprague Dawley rats

Marie-Chantal Giroux1), Pierre Hélie2), Patrick Burns3), and Pascal Vachon1, 4)
1)Faculty of Veterinary Medicine, Departments of Veterinary Biomedicine, University of Montreal, 3200 rue Sicotte, Saint-Hyacinthe, Quebec, J2S 2M2, Canada 2)Faculty of Veterinary Medicine, Departments of Pathology and Microbiology, University of Montreal, Saint-Hyacinthe, Quebec, Canada 3)Faculty of Veterinary Medicine, Departments of Veterinary Clinical Sciences, University of Montreal, Saint-Hyacinthe, Quebec, Canada 4)Sainte-Justine University Hospital Research Center, Montreal, Canada
Abstract :

The main objective of this study was to compare the effects of ketamine and xylazine in aging rats when coadministered intraperitoneally at high anesthetic doses. Three groups (n=6 rats/ group) consisting of rats at 3, 6 and 12 months of age were used. During anesthesia, animals were monitored for heart rate, respiratory frequency, blood oxygen saturation, and rectal temperature. The corneal and paw withdrawal reflex were also examined during anesthesia. During anesthesia, withdrawal and corneal reflexes were absent for progressively longer durations with increasing age. Significant decreases in cardiac and respiratory frequency and, blood oxygen saturation occurred for the 6- and 12-month-old animals. Respiratory frequency and blood oxygen saturation returned to normal at the end of the anesthesia; however, the significant decrease in cardiac frequency persisted in the 6- and 12-month-old animals. Rectal temperature was decreased significantly only in the 3-month-old animals. Pulmonary edema and effusion occurred in 50% of the 12-month-old animals. In conclusion, if ketamine-xylazine are used for anesthesia, the doses should be optimized for the age of the subjects prior to initiation of the research project. 

Keywords :
: aging, anesthesia, ketamine, rats, xylazine

Date Deposited : 07 Jan 2016 10:32

Last Modified : 07 Jan 2016 10:32

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/64/3/_contents

Volume 64, Number 3, March 2015 , ISSN 253–260

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