UMM Logo

Universitas Muhammadiyah Malang


Free Download Journals Directory


Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2015 > Volume 64 Number 3 > Kazuhiko Takamatsu1, 3), Hiroyuki Yamashita2), Shigeru Satake2), Katsuyuki Kazusa1), Hajime Tabata1), and Takahito Nishikata3

Effects of four-week feed restriction on toxicological parameters in beagle dogs

Kazuhiko Takamatsu1, 3), Hiroyuki Yamashita2), Shigeru Satake2), Katsuyuki Kazusa1), Hajime Tabata1), and Takahito Nishikata3
1)Drug Safety Research Laboratories, Astellas Pharma Inc., 2-1-6 Kashima, Yodogawa-ku, Osaka 532-8514, Japan 2)Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., 2438 Miyanoura, Kagoshima 891-1394, Japan 3)Department of Nanobioscience, Frontiers of Innovative Research in Science and Technology, Konan University, 7-1-20 Minatojimaminamimachi, Chuo-ku, Kobe 650-0047, Japan
Abstract :

This study was conducted to examine any changes caused by feed restriction in dogs to contribute to safety evaluation in toxicity studies. Two male 7-month-old beagle dogs/group were fed 300 (control), 150 (50% of control), or 70 g/animal of diet daily (23% of control) for 4 weeks. Effects of feed restriction, except for clinical signs, were noted depending on the feed dosage in almost all examinations. The principal outcomes were: decreased body weight and water consumption, ECG changes (decreased heart rate and prolonged QTc), and hematopoietic and lymphopoietic suppression (decreased reticulocyte ratio or white blood cell count in hematology, decreased nucleated cell count in bone marrow, decreased erythroid parameters in myelography, and hypocellularity of bone marrow and thymic atrophy in histopathology). In addition, some changes were noted in urinalysis (decreased urine volume and sodium and potassium excretion), blood chemistry (decreased ALP and inorganic phosphorus and increased creatinine), organ weights, and gastric histopathology. These results provide important reference data for distinguishing the primary effects of test compounds from secondary effects of decreased food consumption in toxicity studies in beagle dogs

Keywords :
beagle dogs, bone marrow, electrocardiography, feed restriction, toxicological parameter

Date Deposited : 07 Jan 2016 10:37

Last Modified : 07 Jan 2016 10:37

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/64/3/_contents

Volume 64, Number 3, March 2015 , ISSN 269–280

Download:
Full Text Original
Abstract : pdf doc
Home | Peta Situs | Admissions | Student Research | E-Journal
Universitas Muhammadiyah Malang © 2011
Developed by Infokom UMM
Last Update : 13 December 2016 20:46Kumpulan file jurnal