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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2015 > Volume 64 Number 3 > Makoto Asahina, Fumi Shimizu, Masayuki Ohta, Michiyasu Takeyama, and Ryuichi Tozawa

Human apolipoprotein B transgenic SHR/NDmcr-cp rats show exacerbated kidney dysfunction

Makoto Asahina, Fumi Shimizu, Masayuki Ohta, Michiyasu Takeyama, and Ryuichi Tozawa
Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2chome, Fujisawa, Kanagawa 251-8555, Japan
Abstract :

Nephropathy frequently co-occurs with metabolic syndrome in humans. Metabolic syndrome is a cluster of metabolic diseases including obesity, diabetes, hypertension, and dyslipidemia, and some previous studies revealed that dyslipidemia contributes to the progression of kidney dysfunction. To establish a new nephropathy model with metabolic syndrome, we produced human apolipoprotein B (apoB) transgenic (Tg.) SHR/NDmcr-cp (SHR-cp/cp) rats, in which dyslipidemia is exacerbated more than in an established metabolic syndrome model, SHR-cp/cp rats. Human apoB Tg. SHR-cp/ cp rats showed obesity, hyperinsulinemia, hypertension, and severe hyperlipidemia. They also exhibited exacerbated early-onset proteinuria, accompanied by increased kidney injury and increased oxidative and inflammatory markers. Histological analyses revealed the characteristic features of human apoB Tg. SHR-cp/cp rats including prominent glomerulosclerosis with lipid accumulation. Our newly established human apoB Tg. SHR-cp/cp rat could be a useful model for the nephropathy in metabolic syndrome and for understanding the interaction between dyslipidemia and renal dysfunction in metabolic syndrome.

Keywords :
apolipoprotein B, dyslipidemia, kidney dysfunction, metabolic syndrome, SHR/NDmcr-cp rats

Date Deposited : 07 Jan 2016 10:48

Last Modified : 07 Jan 2016 10:48

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/64/3/_contents

Volume 64, Number 3, August 2015 , ISSN 313–321

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