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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2015 > Volume 64 Number 4 > Hitoki Yamanaka1), Tai Nakanishi1), Toshikazu Takagi1,2), Makiko Ohsawa1), Noriaki Kubo1), Naoto Yamamoto1), Takahira Takemoto1), and Kazutaka Ohsawa1)

Helicobacter sp. MIT 01-6451 infection during fetal and neonatal life in laboratory mice

Hitoki Yamanaka1), Tai Nakanishi1), Toshikazu Takagi1,2), Makiko Ohsawa1), Noriaki Kubo1), Naoto Yamamoto1), Takahira Takemoto1), and Kazutaka Ohsawa1)
1)Division of Comparative Medicine, Center for Frontier Life Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan 2)Quality Control Department, Bio Technical Center, Japan SLC, Inc., 3-5-1 Aoihigashi, Naka, Hamamatsu, Shizuoka 433-8114, Japan
Abstract :

: Helicobacter sp. MIT 01-6451 has been detected in SPF mice kept in Japan. To characterize strain MIT 01-6451, its infection route during fetal and neonatal life and effects on pregnancy were investigated using immunocompetent and immunodeficient mouse strains (BALB/c, C57BL/6, and SCID). MIT 01-6451 was detected in the uterus, vagina, and mammary glands of 50% of infected SCID mice, whereas these tissues were all negative in immunocompetent mice. No fetal infections with MIT 01-6451 were detected at 16–18 days after pregnancy in any mouse strain. In newborn mice, MIT 01-6451 was detected in intestinal tissue of C57BL/6 and SCID mice at 9–11 days after birth, but not in BALB/c mice. The IgA and IgG titers to MIT 01-6451 in sera of C57BL/6 female mice were significantly lower than those of BALB/c mice. Although no significant differences in the number of newborns per litter were observed between MIT 01-6451-infected and MIT 01-6451-free dams, the birth rate was lower in infected SCID mice than in control SCID mice. The present results indicated that MIT 01-6451 infects newborn mice after birth rather than by vertical transmission to the fetus via the placenta and that MIT 01-6451 infection shows opportunistically negative effects on the birth rate. In addition, the maternal immune response may affect infection of newborn mice with MIT 01-6451 through breast milk

Keywords :
Helicobacter sp. MIT 01-6451, laboratory mice, reproductive organ, vertical transmission

Date Deposited : 07 Jan 2016 11:11

Last Modified : 07 Jan 2016 11:11

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/64/4/_contents

Volume 64, Number 4, July 2015 , ISSN 375–382

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