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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2015 > Volume 64 Number 4 > Mehmet Aksoy1), Ali Ahiskalioglu1), Ilker Ince1), Mine Celik1), Aysenur Dostbil1), Ufuk Kuyrukluyildiz2), Durdu Altuner3), Nezahat Kurt4), and Halis Suleyman3

The relation between the effect of a subhypnotic dose of thiopental on claw pain threshold in rats and adrenalin, noradrenalin and dopamine levels

Mehmet Aksoy1), Ali Ahiskalioglu1), Ilker Ince1), Mine Celik1), Aysenur Dostbil1), Ufuk Kuyrukluyildiz2), Durdu Altuner3), Nezahat Kurt4), and Halis Suleyman3
1)Department of Anesthesiology and Reanimation, Faculty of Medicine, Ataturk University, 25240, #Erzurum, Turkey 2)Department of Anesthesiology and Reanimation, Faculty of Medicine, Erzincan University, 24030, #Erzincan, Turkey 3)Department of Pharmacology, Faculty of Medicine, Erzincan University, 24030,#Erzincan, Turkey 4)Department of Biochemistry, Faculty of Medicine, Ataturk University,#25340, Erzurum, Turkey
Abstract :

Thiopental sodium (TPS) needs to be applied together with adrenalin in order to establish its analgesic effect in general anesthesia. We aimed to investigate the effect of TPS on the claw pain threshold in rats and evaluated its relationship with endogenous adrenalin (ADR), noradrenalin (NDR), and dopamine (DOP) levels. Intact and adrenalectomized rats were used in the experiment. Intact animals were divided into the following groups: 15 mg/kg TPS (TS), 0.3 mg/kg ADR+15 mg/kg TPS (ATS) and 0.3 mg/kg ADR alone (ADR). Adrenalectomized animals were divided into the following groups: 15 mg/kg TPS (A-TS), 0.3 mg/kg ADR+15 mg/kg TPS (A-ATS) and 0.3 mg/kg ADR alone (A-ADR). Claw pain threshold and blood ADR, NDR, and DOP levels were measured. The TS group’s claw pain threshold was found low. However, the claw pain thresholds of the ATS and ADR groups increased significantly. In the A-TS group, the pain threshold decreased compared with normal, and in the A-ATS and A-ADR groups, the pain threshold increased. TPS reduced the blood ADR levels in intact rats; however, no significant changes were observed in the NDR and DOP levels. #TPS provides hyperalgesia by reducing the production of ADR in rats. The present study shows that to achieve analgesic activity, TPS needs to be applied together with ADR

Keywords :
catecholamines pain, rat, thiopental sodium

Date Deposited : 07 Jan 2016 11:20

Last Modified : 07 Jan 2016 11:20

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/64/4/_contents

Volume 64, Number 4, July 2015 , ISSN 391–396

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