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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2010 > Volume 59 Number 4 > Satoshi IDA1)2), Masaki OHMURAYA1)3), Masahiko HIROTA4), Nobuyuki OZAKI2), Sayaka HIRAMATSU1), Hitoshi UEHARA1), Hiroshi TAKAMORI2), Kimi ARAKI1), Hideo BABA2) and Ken-ichi YAMAMURA1)

Chronic Pancreatitis in Mice by Treatment with Choline-Deficient Ethionine-Supplemented Diet

Satoshi IDA1)2), Masaki OHMURAYA1)3), Masahiko HIROTA4), Nobuyuki OZAKI2), Sayaka HIRAMATSU1), Hitoshi UEHARA1), Hiroshi TAKAMORI2), Kimi ARAKI1), Hideo BABA2) and Ken-ichi YAMAMURA1)
1) Insitute of Resource Development and Analysis, Kumamoto University 2) Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto University 3) Priority Organization for Innovation and Excellence, Kumamoto University 4) Department of Surgery, Kumamoto Regional Medical Center
Abstract :

Although chronic pancreatitis is a risk factor for pancreatic ductal adenocarcinoma (PDA), the relationship between chronic pancreatitis and PDA remains obscure. A critical obstacle to understanding the role of chronic pancreatitis is the lack of animal models. To develop one such model, mice were fed long-term with a choline deficient ethionine-supplemented (CDE) diet. Histological evaluation revealed that chronic pancreatitis, characterized by acinar atrophy, fibrosis and well-developed tubular complexes (TCs), was observed after 24 weeks of CDE diet treatment. Furthermore, expression of epidermal growth factor receptor (EGFR) and its ligands; serine protease inhibitor Kazal type 3 (Spink3) and transforming growth factor α (TGF α) and activation of K-Ras (GTP-Ras formation), which are frequently observed in human PDA, were indeed observed in parallel with TCs formation. Neoplastic lesions were not found after 54 weeks of treatment, suggesting that a continuation of CDE diet or another insult is required for the development of PDA.

Keywords :
CDE diet, chronic pancreatitis, EGFR, Spink3, tubular complex

Date Deposited : 21 Jun 2011 14:27

Last Modified : 21 Jun 2011 14:27

Official URL: http://www.jstage.jst.go.jp/browse/expanim/60/1/_contents

Volume 59, Number 4, - 2010

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