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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2010 > Volume 59 Number 4 > Haruo HASHIMOTO1), Tomoo ETO1), Keiko ENDO1), Gen ITAI1), Tsutomu KAMISAKO1), Hiroshi SUEMIZU1) and Mamoru ITO1)

Comparative Study of Doses of Exogenous Progesterone Administration Needed to Delay Parturition in Jcl:MCH(ICR) Mice

Haruo HASHIMOTO1), Tomoo ETO1), Keiko ENDO1), Gen ITAI1), Tsutomu KAMISAKO1), Hiroshi SUEMIZU1) and Mamoru ITO1)
1) Central Institute for Experimental Animals
Abstract :

The effects of progesterone (P4) used in physiological studies and in delayed parturition in reproductive engineering were examined. A dose of 0.25, 0.5, 1, or 2 mg of P4 was repeatedly administered to Jcl:MCH(ICR) mice on days 17 and 18 of gestation, and plasma concentrations of P4 were investigated. The P4 concentrations in mothers and fetuses after administration of exogenous P4 were no differences between doses of 1 and 2 mg. Jcl:MCH(ICR) mothers administered a P4 dose of 1 mg did not give birth. Therefore, we consider 2 mg of P4 is an overdose and that it is evident that a dose of 1 mg P4 is sufficient to induce delayed parturition.

Keywords :
delayed parturition, Jcl:MCH(ICR) mice, progesterone

Date Deposited : 21 Jun 2011 14:42

Last Modified : 21 Jun 2011 14:42

Official URL: http://www.jstage.jst.go.jp/browse/expanim/60/1/_contents

Volume 59, Number 4, - 2010

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