UMM Logo

Universitas Muhammadiyah Malang


Free Download Journals Directory


Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2010 > Volume 59 Number 4 > Yukihito ISHII1), Mimi MAKI1), Hiromi YAMAMOTO1), Tomohiko SASASE1), Makoto KAKUTANI1) and Takeshi OHTA1)

Evaluation of Blood Pressure in Spontaneously Diabetic Torii-Leprfa Rats

Yukihito ISHII1), Mimi MAKI1), Hiromi YAMAMOTO1), Tomohiko SASASE1), Makoto KAKUTANI1) and Takeshi OHTA1)
1) Japan Tobacco Inc., Central Pharmaceutical Research Institute
Abstract :

The Spontaneously Diabetic Torii-Leprfa (SDT-fa/fa) rat, a new model of obese type 2 diabetes, shows obesity, hyperglycemia, and hyperlipidemia from 6 weeks of age. Diabetic complications such as nephropathy and cataract are observed with aging; however, blood pressure change with age has not previously been examined. In this study, blood pressure was periodically measured and the change was investigated. Blood pressure in male SDT-fa/fa rats was elevated at 8, 16, and 24 weeks of age, whereas the heart rate was not changed. In addition to hyperglycemia, hyperlipidemia, and proteinuria, hyperleptinemia and increased urine angiotensinogen were observed in SDT-fa/fa rats. Blood pressure and heart rate in the male original SDT (SDT-+/+) rat did not significantly change. In conclusion, the SDT-fa/fa rat is a promising model, showing significant hypertension with diabetes mellitus.

Keywords :
blood pressure, diabetes, SDT-fa/fa rat

Date Deposited : 21 Jun 2011 14:44

Last Modified : 21 Jun 2011 14:44

Official URL: http://www.jstage.jst.go.jp/browse/expanim/60/1/_contents

Volume 59, Number 4, - 2010

Download:
Full Text Original
Abstract : pdf doc
Home | Peta Situs | Admissions | Student Research | E-Journal
Universitas Muhammadiyah Malang © 2011
Developed by Infokom UMM
Last Update : 13 December 2016 20:46Kumpulan file jurnal