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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2014 > Volume 10 Number 3 > Yingling Jiang1, 2*, Wei Huang1*, Jing Wang1, Zhipeng Xu1, Jieyu He1, Xiaohong Lin2, Zhiguang Zhou1, Jingjing Zhang1,

Metformin Plays a Dual Role in MIN6 Pancreatic β Cell Function through AMPK-dependent Autophagy

Yingling Jiang1, 2*, Wei Huang1*, Jing Wang1, Zhipeng Xu1, Jieyu He1, Xiaohong Lin2, Zhiguang Zhou1, Jingjing Zhang1,
1. Metabolic Syndrome Research Center and Diabetes Center,Institute of Aging and Geriatric Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China 410011 2. Endocrinology Department, Zhuzhou Central Hospital, Zhuzhou, Hunan, China 412007 * Y. Jiang and W. Huang contributed equally to this work.  Corresponding author: J.Z.: Metabolic Syndrome Research Center, Second Xiangya Hospital, Central South University, No. 139, Middle Renmin Road, Changsha, Hunan 410011, China. Fax: +86 0731 85292148; E-mail address: Doctorzhangjj@gmail.com
Abstract :

Metformin improves insulin sensitivity in insulin sensitive tissues such as liver, muscle and fat. However, the functional roles and the underlying mechanism of metformin action in pancreatic β cells remain elusive. Here we show that, under normal growth condition, metformin suppresses MIN6 β cell proliferation and promotes apoptosis via an AMPK-dependent and autophagy-mediated mechanism. On the other hand, metformin protects MIN6 cells against palmitic acid (PA)-induced apoptosis. Our findings indicate that metformin plays a dual role in β cell survival and overdose of this anti-diabetic drug itself may lead to potential β cell toxicity.

Keywords :
metformin; pancreatic β cells; AMPK; autophagy; apoptosis

Date Deposited : 03 Feb 2016 11:59

Last Modified : 03 Feb 2016 11:59

Official URL: http://www.ijbs.com/v10i3

Volume 10, Number 3, - 2014 , ISSN 1449-2288

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