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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2014 > Volume 10 Number 6 > Michael V. Fiandalo, John Wilton and James L. Mohler 

Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment

Michael V. Fiandalo, John Wilton and James L. Mohler 
Department of Urology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.  Corresponding author: James L. Mohler MD. Department of Urology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263. Telephone: (716) 845-8433 Fax: (716) 845-3300 Email: James.Mohler@RoswellPark.org.
Abstract :

Almost all men who present with advanced prostate cancer (CaP) and many men who fail potentially curative therapy are treated with androgen deprivation therapy (ADT). ADT is not curative and CaP recurs as the lethal phenotype. The goal of this review is to describe the evolution of adrenal androgen blockade, how new androgen measurement methods have furthered understanding of androgen metabolism, and how further understanding of the backdoor pathway of androgen metabolism may lead to interventions that extend survival even more

Keywords :
Adrenal androgens, Backdoor Pathway, Prostate cancer, Dihydrotestosterone, CYP17A1.

Date Deposited : 12 Feb 2016 09:39

Last Modified : 12 Feb 2016 09:39

Official URL: http://www.ijbs.com/v10i6

Volume 10, Number 6, - 2014 , ISSN 1449-2288

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