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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2010 > Volume 59 Number 5 > Toshio HONJO1), Takashi KURIBAYASHI2), Tetsurou SEITA2), Yui MOKONUMA2), Ayaka YAMAGA2), Shunsuke YAMAZAKI3) and Shizuo YAMAMOTO2)

The Effects of Interleukin-6 and Cytokine-Induced Neutrophil Chemoattractant-1 on α2-Macroglobulin Production in Rat

Toshio HONJO1), Takashi KURIBAYASHI2), Tetsurou SEITA2), Yui MOKONUMA2), Ayaka YAMAGA2), Shunsuke YAMAZAKI3) and Shizuo YAMAMOTO2)
1) Seminar on Environment, School of Life and Environmental Science, Azabu University 2) Laboratory of Immunology, School of Life and Environmental Science, Azabu University 3) Laboratory of Physiology, Department of Food and Nutrition, Kamakura Women’s University
Abstract :

We investigated the effects of interleukin-6 (IL-6) and cytokine-induced neutrophil chemoattractant-1 (CINC-1) on α2-macroglobulin (α2M) production in rats. IL-6-rich and CINC-1-rich fractions were separated from serum obtained from rats 12 h after injection with turpentine oil using gel-chromatography. Sexual dimorphism was observed in the peak levels of α2M after injection of IL-6-, CINC-1-, or a mixture of IL-6-and-CINC-1-rich fractions. No significant differences in α2M levels were observed in males after injection with IL-6- or CINC-1-rich fractions and those injected with normal serum obtained from healthy rats (control). In contrast, serum levels of α2M, 6 to 120 h after injection of a mixture of IL-6- and CINC-1-rich fractions were significantly higher than in control rats. These results suggest that IL-6 and CINC-1 contribute to α2M production in rats only when IL-6 and CINC-1 act synergistically.

Keywords :
α2M, CINC-1, cytokine, IL-6, rat

Date Deposited : 21 Jun 2011 15:26

Last Modified : 21 Jun 2011 15:26

Official URL: http://www.jstage.jst.go.jp/browse/expanim/60/1/_contents

Volume 59, Number 5, - 2010

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