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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2010 > Volume 59 Number 5 > Maiko KAWAGUCHI1), Kaori MOROHOSHI2)8), Hideki IMAI3), Masatoshi MORITA4)5), Nobumasa KATO6)7) and Toshiyuki HIMI1)

Maternal Exposure to Isobutyl-Paraben Impairs Social Recognition in Adult Female Rats

Maiko KAWAGUCHI1), Kaori MOROHOSHI2)8), Hideki IMAI3), Masatoshi MORITA4)5), Nobumasa KATO6)7) and Toshiyuki HIMI1)
1) Faculty of Pharmacy and Research Institute of Pharmaceutical Science, Musashino University 2) Biological Risk Assessment Section, Environmental Health Sciences Division, National Institute for Environmental Studies 3) Fuculty of Nursing at Higashigaoka, Tokyo Healthcare University 4) Research Center for Environmental Risk, National Institute for Environmental Studies 5) Department of Bioresources, Faculty of Agriculture, Ehime University 6) CREST 7) Department of Psychiatry, Showa University School of Medicine 8) Mitsubishi Chemical Medience Corporation, Medi-Chem Business Segment, Toxicological Science Division, Yokohama Laboratory
Abstract :

Isobutyl-paraben (IBP), a widely used preservative, exhibits estrogenic activity. We analyzed the effects of exposure to IBP during gestation and lactation via dam on social recognition behavior in ovariectomized offspring of Sprague-Dawley rats. Offspring were ovariectomized at 7 weeks of age, and were used in a social recognition test at 16 weeks of age. Each offspring was exposed to a novel ovariectomized rat four times and to a second novel rat in a fifth exposure. We counted the investigations by offspring of intruder rats. The IBP-exposed rats showed impaired social behavior compared with controls. These data imply that early exposure to IBP may have an effect on adult social behavior, which is reported to be an autism spectrum disorders in humans.

Keywords :
isobutyl-paraben, rat, social recognition

Date Deposited : 21 Jun 2011 15:36

Last Modified : 21 Jun 2011 15:36

Official URL: http://www.jstage.jst.go.jp/browse/expanim/60/1/_contents

Volume 59, Number 5, - 2010

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