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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2015 > Volume 11 Number 2 > Abualgasim Elgaili Abdalla1, 2, Qiming Li1, Longxiang Xie1, Jianping Xie1

Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis

Abualgasim Elgaili Abdalla1, 2, Qiming Li1, Longxiang Xie1, Jianping Xie1
1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China. 2. Department of Clinical Microbiology, College of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Khartoum, Sudan. Corresponding author: Jianping Xie. E-mail: georgex@swu.edu.cn; Tel&Fax: 862368367108
Abstract :

IL-27, a heterodimeric cytokine of IL-12 family, regulates both innate and adaptive immunity largely via Jak-Stat signaling. IL-27 can induce IFN-γ and inflammatory mediators from T lymphocytes and innate immune cells. IL-27 has unique anti-inflammatory properties via both Tr1 cells dependent and independent mechanisms. Here the role and biology of IL-27 in innate and adaptive immunity are summarized, with special interest with immunity against Mycobacterium tuberculosis.

Keywords :
IL-27; IL-27Rα; IL-12 family; Mycobacterium tuberculosis; Immunity

Date Deposited : 17 Feb 2016 11:44

Last Modified : 17 Feb 2016 11:44

Official URL: http://www.ijbs.com/v11i2

Volume 11, Number 2, - 2015 , ISSN 1449-2288

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