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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2010 > Volume 59 Number 5 > Hiroyuki SAKAKIBARA1)2), Akiharu KOYANAGI1), Taka-aki SUZUKI3), Atsumi SUZUKI1), Lin LING1) and Kayoko SHIMOI1)2)4)

Effects of Animal Care Procedures on Plasma Corticosterone Levels in Group-Housed Mice during the Nocturnal Active Phase

Hiroyuki SAKAKIBARA1)2), Akiharu KOYANAGI1), Taka-aki SUZUKI3), Atsumi SUZUKI1), Lin LING1) and Kayoko SHIMOI1)2)4)
1) Graduate School of Nutritional and Environmental Sciences, University of Shizuoka 2) Institute for Environmental Sciences, University of Shizuoka 3) Shizuoka Industrial Research Institute 4) Global COE program, University of Shizuoka
Abstract :

 C57BL/6 mice were housed five per cage on a 12:12 h light/dark cycle. All animal care, including bed cleaning, was carried out during the nonactive phase. After 2 weeks, mean plasma corticosterone levels, collected during the nonactive (ZT6) and active (ZT18) phases, were 66.0 and 270.9 ng/ml, respectively. The values at ZT18 gradually increased in the order of the mice used for blood collection, but not at ZT6. When animal care was carried out at ZT18, the increasing pattern of plasma corticosterone levels previously observed at ZT18 was less pronounced after 2 weeks of acclimatization, and was not observed after 4 weeks. Therefore, animal care should be carried out in the active phase for at least 4 weeks before experiments involving stress responses in the active phase.

Keywords :
active phase, animal care, stress

Date Deposited : 21 Jun 2011 15:37

Last Modified : 21 Jun 2011 15:37

Official URL: http://www.jstage.jst.go.jp/browse/expanim/60/1/_contents

Volume 59, Number 5, - 2010

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