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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2015 > Volume 11 Number 2 > Lina Huang, Wenya Ma, Yidi Ma, Dan Feng, Hongyang Chen, Benzhi Cai

Exosomes in Mesenchymal Stem Cells, a New Therapeutic Strategy for Cardiovascular Diseases?

Lina Huang, Wenya Ma, Yidi Ma, Dan Feng, Hongyang Chen, Benzhi Cai
Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 150081, China. Corresponding author: Dr. Benzhi Cai, Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157# Baojian Road, Nangang District, Harbin 150081, Heilongjiang, China; Tel.: +86 451 8666-9473; Fax: +86 451 8667-1354; Email: caibz@ems.hrbmu.edu.cn
Abstract :

Cardiovascular diseases (CVDs) are still a major cause of people deaths worldwide, and mesenchymal stem cells (MSCs) transplantation holds great promise due to its capacity to differentiate into cardiovascular cells and secrete protective cytokines, which presents an important mechanism of MSCs therapy for CVDs. Although the capability of MSCs to differentiate into cardiomyocytes (CMCs), endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) has been well recognized in massive previous experiments both in vitro and in vivo, low survival rate of transplanted MSCs in recipient hearts suggests that therapeutic effects of MSCs transplantation might be also correlated with other underlying mechanisms. Notably, recent studies uncovered that MSCs were able to secret cholesterol-rich, phospholipid exosomes which were enriched with microRNAs (miRNAs). The released exosomes from MSCs acted on hearts and vessels, and then exerted anti-apoptosis, cardiac regeneration, anti-cardiac remodeling, anti-inflammatory effects, neovascularization and anti-vascular remodeling, which are considered as novel molecular mechanisms of therapeutic potential of MSCs transplantation. Here we summarized recent advances about the role of exosomes in MSCs therapy for CVDs, and discussed exosomes as a novel approach in the treatment of CVDs in the future.

Keywords :
microRNA, exosomes, mesenchymal stem cell, myocardial infarction, reperfusion injury, pulmonary hypertension

Date Deposited : 17 Feb 2016 11:46

Last Modified : 17 Feb 2016 11:46

Official URL: http://www.ijbs.com/v11i2

Volume 11, Number 2, - 2015 , ISSN 1449-2288

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