UMM Logo

Universitas Muhammadiyah Malang


Free Download Journals Directory


International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2015 > Volume 11 Number 3 > Mamdooh H. Ghoneum1, Nariman K. Badr El-Din2, Salma M. Abdel Fattah3, Deyu Pan4, and Lucilene Tolentino5

Hydroferrate Fluid, MRN-100, Provides Protection against Chemical-Induced Gastric and Esophageal Cancer in Wistar Rats

Mamdooh H. Ghoneum1, Nariman K. Badr El-Din2, Salma M. Abdel Fattah3, Deyu Pan4, and Lucilene Tolentino5
1. Department of Otolaryngology, Charles Drew University of Medicine and Science, 1731 E. 120th Street, Los Angeles, CA 90059, USA. 2. Department of Zoology, Faculty of Science, University of Mansoura, Mansoura 35516, Egypt. 3. Drug and Radiation Research Department, National Center for Radiation and Research Technology, P.O. Box 29 Nasr City, Cairo, Egypt. 4. Department of Internal Medicine, Charles Drew University of Medicine and Science, 1731 E. 120th Street, Los Angeles, CA 90059, USA. 5. Department of Pathology, Charles Drew University of Medicine and Science, 1731 E. 120th Street, Los Angeles, CA 90059, USA.  Corresponding author: Mamdooh H. Ghoneum, Ph. D. Address: 1731 E. 120th Street, Los Angeles, CA 90059. Email: mghoneum@ucla.edu. Phone: (310) 474-6724/(323) 562-5953. Fax: (310)474-6724
Abstract :

In the current study, we examined the protective effect of hydroferrate fluid MRN-100 against the carcinogen methylnitronitrosoguanidine (MNNG)-induced gastric and esophageal cancer in rats. MRN-100 is an iron-based compound composed of bivalent and trivalent ferrates. At 33 weeks post treatment with MNNG, rats were killed and examined for the histopathology of esophagus and stomach; liver, spleen, and total body weight; and antioxidant levels in the blood and stomach tissues. Results showed that 17/20 (85%) gastroesophageal tissues from carcinogen MNNG-treated rats developed dysplasia and cancer, as compared to 8/20 (40%) rats treated with MNNG plus MRN-100. In addition, MRN-100 exerted an antioxidant effect in both the blood and stomach tissues by increasing levels of GSH, antioxidant enzymes SOD, CAT, and GPx, and total antioxidant capacity (TAC) level. This was accompanied by a reduction in the total free-radical and malondialdehyde levels. Furthermore, MRN-100 protected against body and organ weight loss. Thus, MRN-100 exhibited significant cancer chemopreventive activity by protecting tissues against oxidative damage in rats, which may suggest its effectiveness as an adjuvant for the treatment of gastric/esophageal carcinoma.

Keywords :
hydroferrate, gastric cancer, dysplasia, anti-oxidant

Date Deposited : 22 Feb 2016 09:32

Last Modified : 22 Feb 2016 09:32

Official URL: http://www.ijbs.com/v11i3

Volume 11, Number 3, - 2015 , ISSN 1449-2288

Download:
Full Text Original
Abstract : pdf doc
Home | Peta Situs | Admissions | Student Research | E-Journal
Universitas Muhammadiyah Malang © 2011
Developed by Infokom UMM
Last Update : 13 December 2016 20:46Kumpulan file jurnal