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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2015 > Volume 11 Number 3 > Guoda Ma1, 2, Yajun Wang3, You Li1, Lili Cui1, Yujuan Zhao4, Bin Zhao2, Keshen Li 1

MiR-206, a Key Modulator of Skeletal Muscle Development and Disease

Guoda Ma1, 2, Yajun Wang3, You Li1, Lili Cui1, Yujuan Zhao4, Bin Zhao2, Keshen Li 1
1. Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China; 2. Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China; 3. Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China; 4. Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.  Corresponding author: E-mail: binzhaoe@163.com (B. Zhao) or likeshen1971@126.com (K. Li). Tel & Fax: +86 759 2386949
Abstract :

MicroRNAs (miRNAs) have recently emerged as fundamental post-transcriptional regulators inhibit gene expression linked to various biological processes. MiR-206 is one of the most studied and best characterized miRNA to date, which specifically expressed in skeletal muscle. In this review, we summarized the results of studies of miR-206 with emphasis on its function in skeletal muscle development. Importantly, dysregulation of miR-206 has been linked to many disorders in skeletal muscle such as Duchenne muscular dystrophy (DMD) and amyotrophic lateral sclerosis (ALS), and circulating miR-206 has highlighted its potential as a diagnose biomarker. In addition, a mutation in the 3’ untranslated region (3’-UTR) of the myostatin gene in the Texel sheep creating a target site for the miR-206 and miR-1 leads to inhibition of myostatin expression, which likely to cause the muscular hypertrophy phenotype of this breed of sheep. Therefore, miR-206 may become novel target for ameliorating skeletal muscle-related disorders and optimization of muscle quantity of domestic animals.

Keywords :
miR-206, skeletal muscle, development, disease

Date Deposited : 22 Feb 2016 09:52

Last Modified : 22 Feb 2016 09:52

Official URL: http://www.ijbs.com/v11i3

Volume 11, Number 3, - 2015 , ISSN 1449-2288

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