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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2015 > Volume 11 Number 4 > Sheila Figel Dwyer, Lingqiu Gao and Irwin H. Gelman

Identification of Novel Focal Adhesion Kinase Substrates: Role for FAK in NFκB Signaling

Sheila Figel Dwyer, Lingqiu Gao and Irwin H. Gelman
Department of Cancer Genetics, Roswell Park Cancer Institute, USA.  Corresponding author: Irwin H. Gelman, Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets Buffalo, NY 14263, 716-845-7681, Irwin.gelman@roswellpark.org
Abstract :

Focal adhesion kinase (FAK) is a major signaling molecule which functions downstream of integrins or in conjunction with mitogenic signaling pathways. FAK is overexpressed and/or activated in many types of human tumors, in which it promotes cell adhesion, survival, migration and invasion. In addition to FAK’s ability to regulate signaling through its scaffolding activities, FAK encodes an intrinsic kinase activity. Although some FAK substrates have been identified, a more comprehensive analysis of substrates is lacking. In this study, we use a protein microarray to screen the human proteome for FAK substrates. We confirm that several of the proteins identified are bona fide in vitro FAK substrates, including several factors which are known to regulate the NFκB pathway. Finally, we identify a role for FAK’s kinase activity in both canonical and non-canonical NFκB signaling. Our screen therefore represents the first high throughput screen for FAK substrates and provides the basis for future in-depth analysis of the role of FAK’s kinase activity in the processes of tumorigenesis.

Keywords :
FAK, substrates, phosphotyrosine, kinase, NFκB, IKKα.

Date Deposited : 22 Feb 2016 10:21

Last Modified : 22 Feb 2016 10:21

Official URL: http://www.ijbs.com/v11i4

Volume 11, Number 4, - 2015 , ISSN 1449-2288

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