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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2015 > Volume 11 Number 7 > Jicheng Chen1,2, Ning Hou2, Chong Zhang1,2, Yan Teng2, Xuan Cheng2, Zhenhua Li2, Jie Ren3, Jian Zeng2, Rui Li2, Wei Wang3, Xiao Yang1,2, and Yu Lan2,

Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility

Jicheng Chen1,2, Ning Hou2, Chong Zhang1,2, Yan Teng2, Xuan Cheng2, Zhenhua Li2, Jie Ren3, Jian Zeng2, Rui Li2, Wei Wang3, Xiao Yang1,2, and Yu Lan2,
1. Model Organism Division, E-institutes of Shanghai Universities, Shanghai Jiaotong University, Shanghai 200025, China 2. State Key Laboratory of Proteomics, Collaborative Innovation Center for Cardiovascular Disorders, Genetic Laboratory of Development and Disease, Institute of Biotechnology, Beijing 100071, China 3. Department of Cardiovascular Electrophysiology Research, College of Basic Medicine, Capital Medical University, Beijing 100069, China These authors contributed equally to this work. Corresponding authors: Xiao Yang, Ph.D., Tel/Fax: 86-10-63895937; E-mail: yangx@bmi.ac.cn. Yu Lan, Ph.D., Tel: 86-10-66948884; E-mail: rainyblue_1999@126.com
Abstract :

As a master component of endosomal sorting complex required for transport proteins, hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) participates multiple cellular behaviors. However, the physiological role of Hgs in smooth muscle cells (SMCs) is by far unknown. Here we explored the in vivo function of Hgs in SMCs by using a conditional gene knockout strategy. Hgs deficiency in SMCs uniquely led to a progressive dilatation of esophagus with a remarkable thinning muscle layer. Of note, the mutant esophagus showed a decreased contractile responsiveness to potassium chloride and acetylcholine stimulation. Furthermore, an increase in the inhibitory neurites along with an intense infiltration of T lymphocytes in the mucosa and muscle layer were observed. Consistently, Hgs deficiency in SMCs resulted in a disturbed expression of a set of genes involved in neurotrophin and inflammation, suggesting that defective SMC might be a novel source for excessive production of cytokines and chemokines which may trigger the neuronal dysplasia and ultimately contribute to the compromised esophageal motility. The data suggest potential implications in the pathogenesis of related diseases such as gastroesophageal reflux disease.

Keywords :
hepatocyte growth factor-regulated tyrosine kinase substrate; smooth muscle cell; esophageal motility; inhibitory neurite; inflammation

Date Deposited : 25 Feb 2016 11:25

Last Modified : 25 Feb 2016 11:25

Official URL: http://www.ijbs.com/v11i7

Volume 11, Number 7, - 2015 , ISSN 1449-2288

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