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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2015 > Volume 11 Number 8 > Aixue Huang , Jie Dong, Shaohua Li, Chaonan Wang, Hongmei Ding , Hui Li , Xueting Su , Xingfeng Ge , Leqiao Sun, Chenjun Bai, Xuelian Shen, Tao Fang, Jie Li , Ningsheng Shao 

Exosomal Transfer of Vasorin Expressed in Hepatocellular Carcinoma Cells Promotes Migration of Human Umbilical Vein Endothelial Cells

Aixue Huang , Jie Dong, Shaohua Li, Chaonan Wang, Hongmei Ding , Hui Li , Xueting Su , Xingfeng Ge , Leqiao Sun, Chenjun Bai, Xuelian Shen, Tao Fang, Jie Li , Ningsheng Shao 
Beijing Institute of Basic Medical Sciences, Beijing 100850, China  Corresponding authors: Ningsheng Shao: E-mail: shaonsh@bmi.ac.cn, Tel: +86 10 66932311; Jie Li: E-mail: jannbio@163.com, Tel: +86 10 66932313;
Abstract :

Vasorin (VASN) is a type I transmembrane protein that plays important roles in tumor development and vasculogenesis. In this paper, we showed that VASN could be a key mediator of communication between tumor cells and endothelial cells. We confirmed for the first time that HepG2-derived VASN can be transferred to human umbilical vein endothelial cells (HUVECs) via receptor mediated endocytosis of exosomes, at least in part through HSPGs. The HepG2-derived VASN containing exosomes promote migration of recipient HUVECs cells. Our results identify a novel pathway by which a functional protein expressed in tumor cells affects the biological fate of endothelial cells via exosomes.

Keywords :
Vasorin; exosomes; endocytosis; angiogenesis; tumor metastasis

Date Deposited : 01 Mar 2016 10:54

Last Modified : 01 Mar 2016 10:54

Official URL: http://www.ijbs.com/v11i8

Volume 11, Number 8, - 2015 , ISSN 1449-2288

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