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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2015 > Volume 11 Number 9 > Muhammad Khan1, Amara Maryam1, Javed Iqbal Qazi2, and Tonghui Ma1

Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells

Muhammad Khan1, Amara Maryam1, Javed Iqbal Qazi2, and Tonghui Ma1
1. College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116044, P.R. China. 2. Department of Zoology, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan.  Corresponding author: Tonghui Ma, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116044, P.R. China. Tel:+86-411-86110278, Fax:+86-411-86110378, E-mail: tonghuima@dlmedu.edu.cn
Abstract :

Cancer is the second leading cause of deaths worldwide. Despite concerted efforts to improve the current therapies, the prognosis of cancer remains dismal. Highly selective or specific blocking of only one of the signaling pathways has been associated with limited or sporadic responses. Using targeted agents to inhibit multiple signaling pathways has emerged as a new paradigm for anticancer treatment. Icariside II, a flavonol glycoside, is one of the major components of Traditional Chinese Medicine Herba epimedii and possesses multiple biological and pharmacological properties including anti-inflammatory, anti-osteoporosis, anti-oxidant, anti-aging, and anticancer activities. Recently, the anticancer activity of Icariside II has been extensively investigated. Here, in this review, our aim is to give our perspective on the current status of Icariside II, and discuss its natural sources, anticancer activity, molecular targets and the mechanisms of action with specific emphasis on apoptosis pathways which may help the further design and conduct of preclinical and clinical trials. Icariside II has been found to induce apoptosis in various human cancer cell lines of different origin by targeting multiple signaling pathways including STAT3, PI3K/AKT, MAPK/ERK, COX-2/PGE2 and β-Catenin which are frequently deregulated in cancers, suggesting that this collective activity rather than just a single effect may play an important role in developing Icariside II into a potential lead compound for anticancer therapy. This review suggests that Icariside II provides a novel opportunity for treatment of cancers, but additional investigations and clinical trials are still required to fully understand the mechanism of therapeutic effects to further validate it in anti-tumor therapy

Keywords :
Icariside II, Herba epimedii, Cancer, Multiple signaling pathways, Apoptosis

Date Deposited : 04 Mar 2016 12:59

Last Modified : 04 Mar 2016 12:59

Official URL: http://www.ijbs.com/v11i9

Volume 11, Number 9, - 2015 , ISSN 1449-2288

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