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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2015 > Volume 11 Number 10 > Hongyi Zhu1, Xiangguo Cheng1,2, Xin Niu2, Yuelei Zhang1, Junjie Guan1, Xiaolin Liu1, Shicong Tao1, Yang Wang1,2, Changqing Zhang1,2

Proton-sensing GPCR-YAP Signalling Promotes Cell Proliferation and Surviva

Hongyi Zhu1, Xiangguo Cheng1,2, Xin Niu2, Yuelei Zhang1, Junjie Guan1, Xiaolin Liu1, Shicong Tao1, Yang Wang1,2, Changqing Zhang1,2
1. Department of Orthopaedic Surgery, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai 200233, China. 2. Institute of Microsurgery on Extremities, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai 200233, China.  Corresponding authors: Tel: +86 21 64369181; Fax: +86 21 6470 1361; Email: zhangcq@sjtu.edu.cn (Changqing Zhang); Tel: +86 18930174249; Fax: +86 21 6470 1361; Email: wangy63cn@126.com (Yang Wang)
Abstract :

The pHs of extracellular fluids (ECFs) in humans are consistently maintained at 7.35 to 7.45 in physiological conditions. Pathological changes, including infarction, tumourigenesis and inflammation, commonly result in decreases in the ECF pH in the affected tissues. In this study, we report that proliferation is promoted and apoptosis is inhibited by decreases in extracellular pH. Furthermore, we demonstrated that proton-sensing G-protein-coupled receptors (GPCRs) are required for the pH-dependent regulation of proliferation and apoptosis through the G protein α subunit 12/13 (G12/13) and Rho GTPases. Next, we identified Yes-associated protein 1 (YAP) as a downstream effector of Rho signalling. Together, the results from our study demonstrate that extracellular pH can modulate cell proliferation and apoptosis by regulating the proton-sensing GPCR-YAP pathway.

Keywords :
pH, YAP, proton-sensing, GPCR, proliferation, apoptosis

Date Deposited : 08 Mar 2016 10:38

Last Modified : 08 Mar 2016 10:38

Official URL: http://www.ijbs.com/v11i10

Volume 11, Number 10, - 2015 , ISSN 1449-2288

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