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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2016 > Volume 12 Number 1 > Yuanhong Zheng, Guifang Yin, Vanminh Le, Anle Zhang, Siyu Chen, Xin Liang, Jianwen Liu

Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy

Yuanhong Zheng, Guifang Yin, Vanminh Le, Anle Zhang, Siyu Chen, Xin Liang, Jianwen Liu
1. State Key Laboratory of Bioreactor Engineering & Shanghai Key Laboratory of New Drug Design, School of pharmacy, East China University of Science and Technology, #268, 130 Meilong Road, Shanghai 200237, PR China 2. Department of Oncology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, P.R. China Corresponding authors: Jianwen Liu, Ph.D., Professor; Xin Liang, Ph.D.; Professor; Siyu Chen, Ph.D., Professor. Tel. /fax: +86 21 64252044; +86 21 52665957; +86-21-25077642. E-mail address: liujian@ecust.edu.cn (J.W. Liu); xin.liang@ecust.edu.cn (X. L.); siyu.chen@shsmu.edu.cn (S.Y. Chen).
Abstract :

Photodynamic therapy (PDT), a regulatory approved cancer treatment, is reported to be capable of causing immunogenic apoptosis. The current data reveal PDT can cause the dysregulation of “eat me” and “don’t eat me” signal by generating reactive oxygen species (ROS) -mediated endoplasmic reticulum (ER) stress. This dysregulation probably contribute to the increased uptake of PDT-killed Lewis lung carcinoma (LLC) cells by homologous dendritic cells (DCs), accompanied by phenotypic maturation (CD80high, CD86high, and CD40high) and functional stimulation (NOhigh, IL-10absent) of dendritic cells as well as subsequent T-cell responses. Morevover, C57BL/6 mice vaccinated with dendritic cells (DCs) pulsed with PDT-treated LLCs (PDT-DCs) or PDT-treated LLCs alone (PDT-LLCs) exhibited potent immunity against LLC tumors. In the current study, the PDT-induced immune response was characterized as a process related with the dysregulation of “eat me” signal and “don’t eat me” signal, revealing the possibility for developing PDT into an antitumor vaccination strategy for personalized cancer immunotherapy

Keywords :
DAMPs; Immunogenic apoptosis; Antitumor vaccination; Hypericin; CD47

Date Deposited : 15 Mar 2016 11:00

Last Modified : 15 Mar 2016 11:00

Official URL: http://www.ijbs.com/v12i1

Volume 12, Number 1, - 2016 , ISSN 1449-2288

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