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.: Home > Animal Science Papers and Reports > 2011 > Volume 29 Number 2 > Bo؟ena Witek1,*, Ewa Ochwanowska1, Artur Wrَbel2, Adam Ko³¹taj3

Effect of morphine on activity of five selected lysosomal enzymes in liver and kidneys of mice

Bo؟ena Witek1,*, Ewa Ochwanowska1, Artur Wrَbel2, Adam Ko³¹taj3
1 Department of Animal Physiology, Institute of Biology, The Jan Kochanowski University in Kielce, 25-406 Kielce, Poland 2 Department of Dental Medicine, Kielce, Poland 3 Polish Academy of Sciences Institute of Genetics and Animal Breeding, 05-552 Wَlka Kosowska, Poland
Abstract :

The experiment was carried out on 90 Swiss male mice divided into 9 groups (n=10). Over 4, 10 and
14 days mice of three control groups (I-III) were injected with 250 ىl 0.9% NaCl solution daily, and
those from six experimental groups (A-F) with 250 ىl 0.9% NaCl solution containing 20 or 30 mg
morphine hydrochloride per kg body weight. The injections were given intramuscularly once a day
between 9:00-10:00 a.m. for 4, 10 and 14 days.
In the lysosomal fraction of the liver and kidney the activities of acid phosphatase, lysosomal esterase,
â-glucuronidase, â-galactosidase, and â-N-acetyl-hexosaminidase were estimated. Morphine
increased the activity of all examined enzymes except EL, which activity was statistically proven to
decrease in liver and kidneys after 10 days morphine administration in both doses.

Keywords :
kidney / liver / lysosomal enzymes / mice

Date Deposited : 21 Jun 2011 16:13

Last Modified : 21 Jun 2011 16:13

Official URL:

Volume 29, Number 2, - 2011

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