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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2016 > Volume 12 Number 3 > Junli Guo, Keping Xie, Shaojiang Zheng

Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer

Junli Guo, Keping Xie, Shaojiang Zheng
1. Department of Pathology, Affiliated Hospital of Hainan Medical College, Hainan Cancer Hospital, Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Haikou 571199, People’s Republic of China 2. Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA  Corresponding authors: Shaojiang Zheng, M.D., Ph.D., Department of Pathology, Affiliated Hospital of Hainan Medical College, Hainan Cancer Hospital, Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, 3 Xueyuan Road, Haikou, Hainan 571199, People’s Republic of China. Tel and Fax: +86 898 667 233 33; E-mail: zhenghoho@aliyun.com; or Keping Xie, M.D., Ph.D., Department of Gastroenterology, Hepatology and Nutrition, Unit 426, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Tel: 713-834-6685; Fax: 713-745 1163; E-mail: kepxie@mdanderson.org.
Abstract :

Lack of early detection and effective interventions is a major reason for the poor prognosis and dismal survival rates for pancreatic cancer. Pancreatic intraepithelial neoplasia (PanIN) is the most common precursor of invasive pancreatic ductal adenocarcinoma (PDAC). Each stage in the progression from PanIN to PDAC is well characterized by multiple significant genetic alterations affecting signaling pathways. Understanding the biological behavior and molecular alterations in the progression from PanIN to PDAC is crucial to the identification of noninvasive biomarkers for early detection and diagnosis and the development of preventive and therapeutic strategies for control of pancreatic cancer progression. This review focuses on molecular biomarkers of PanIN and their important roles in early detection and treatment of pancreatic cancer.

Keywords :
PanINs; Biomarker; Early Diagnosis; Therapeutic Intervention

Date Deposited : 16 Mar 2016 11:11

Last Modified : 16 Mar 2016 11:11

Official URL: http://www.ijbs.com/v12i3

Volume 12, Number 3, - 2016 , ISSN 1449-2288

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