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.: Home > Nature and Science > 2012 > Volume 10 Number 9 > Hassan A. El-Sayed* and Nabil H. Ouf

An Efficient and Facile Multicomponent Synthesis of 4,6-Diarylpyridine Derivatives under Solvent-Free Conditions

Hassan A. El-Sayed* and Nabil H. Ouf
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt haabel81@yahoo.com
Abstract :

An efficient and facile synthesis of 4,6-diaryl-2-oxo-1,2-dihydropyridine-3-carbonitriles (4a-j) via four-component system for aromatic aldehydes 1, acetophenones (2), ethyl cyanoacetate (3) and ammonium acetate. The short reaction time coupled with the simplicity of the reaction procedure and clean reaction make this method one of the most efficient methods for the synthesis of this class of compounds.

Keywords :
multicomponent synthesis, Solvent-Free Conditions and pyridine-3-carbonitrile

Date Deposited : 18 May 2016 19:43

Last Modified : 18 May 2016 19:43

Official URL: http://www.sciencepub.net/nature/

Volume 10, Number 9, - 2012 , ISSN 1545-0740

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