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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2016 > Volume 65 Number 1 > Ján LÍŠKA1), Július BRTKO2), Michal DUBOVICKÝ3), Dana MACEJOVÁ2), Viktória KISSOVÁ4), Štefan POLÁK1), and Eduard UJHÁZY3)

Relationship between histology, development and tumorigenesis of mammary gland in female rat

Ján LÍŠKA1), Július BRTKO2), Michal DUBOVICKÝ3), Dana MACEJOVÁ2), Viktória KISSOVÁ4), Štefan POLÁK1), and Eduard UJHÁZY3)
1)Institute of Histology and Embryology, Medical Faculty of Comenius University, Sasinkova 4, Bratislava 811 08, Slovak Republic 2)Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlárska 3, Bratislava 833 06, Slovak Republic 3)Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava 841 04, Slovak Republic 4)Department of Pathological Anatomy, University of Veterinary Medicine and Pharmacy, Komenského 73, Košice 041 81, Slovak Republic
Abstract :

The mammary gland is a dynamic organ that undergoes structural and functional changes associated with growth, reproduction, and post-menopausal regression. The postnatal transformations of the epithelium and stromal cells of the mammary gland may contribute to its susceptibility to carcinogenesis. The increased cancer incidence in mammary glands of humans and similarly of rodents in association with their development is believed to be partly explained by proliferative activity together with lesser degree of differentiation, but it is not completely understood how the virgin gland retains its higher susceptibility to carcinogenesis. During its developmental cycle, the mammary gland displays many of the properties associated with breast cancer. An early first full-term pregnancy may have a protective effect. Rodent models are useful for investigating potential breast carcinogens. The purpose of this review is to help recognizing histological appearance of the epithelium and the stroma of the normal mammary gland in rats, and throughout its development in relation to tumorigenic potential.

Keywords :
carcinogenesis, development, histology, mammary gland, rat

Date Deposited : 24 Jun 2016 18:50

Last Modified : 24 Jun 2016 18:50

Official URL: http://

Volume 65, Number 1, - 2016 , ISSN 1341-1357

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