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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2016 > Volume 12 Number 7 > Chia-Ing Jan1,2, Ming-Hsui Tsai3, Chang-Fang Chiu4, Yi-Ping Huang5, Chia Jen Liu6, Nai Wen Chang6

Fenofibrate Suppresses Oral Tumorigenesis via Reprogramming Metabolic Processes: Potential Drug Repurposing for Oral Cancer

Chia-Ing Jan1,2, Ming-Hsui Tsai3, Chang-Fang Chiu4, Yi-Ping Huang5, Chia Jen Liu6, Nai Wen Chang6
1. Department of Pathology, China Medical University and Hospital, Taichung, Taiwan, ROC 2. Department of Pathology, China Medical University and Beigang Hospital, Yunlin, Taiwan.TOC. 3. Department of Otolaryngology, China Medical University and Hospital, Taichung, Taiwan, ROC. 4. Department of Hematology Oncology, China Medical University and Hospital, Taichung, Taiwan, ROC. 5. Department of Physiology, College of Medicine, China Medical University, Taichung, Taiwan, ROC. 6. Department of Biochemistry, College of Medicine, China Medical University, Taichung, Taiwan, ROC.  Corresponding author: Department of Biochemistry, College of Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 404, Taiwan, ROC. Tel: +886 4 22053366 ext 2151. Fax: +886 4 22053764. E-mail: nwchang@mail.cmu.edu.tw.
Abstract :

One anticancer strategy suggests targeting mitochondrial metabolism to trigger cell death through slowing down energy production from the Warburg effect. Fenofibrate is a clinical lipid-lowering agent and an effective anticancer drug. In the present study, we demonstrate that fenofibrate provided novel mechanisms for delaying oral tumor development via the reprogramming of metabolic processes. Fenofibrate induced cytotoxicity by decreasing oxygen consumption rate (OCR) that was accompanied with increasing extracellular acidification rate (ECAR) and reducing ATP content. Moreover, fenofibrate caused changes in the protein expressions of hexokinase II (HK II), pyruvate kinase, pyruvate dehydrogenase, and voltage-dependent anion channel (VDAC), which are associated with the Warburg effect. In addition, fenofibrate reprogrammed the metabolic pathway by interrupting the binding of HK II to VDAC. In an oral cancer mouse model, fenofibrate exhibited both preventive and therapeutic efficacy on oral tumorigenesis. Fenofibrate administration suppressed the incidence rate of tongue lesions, reduced the tumor sizes, decreased the tumor multiplicity, and decreased the immunoreactivities of VDAC and mTOR. The molecular mechanisms involved in fenofibrate’s ability to delay tumor development included the down-regulation of mTOR activity via TSC1/2-dependent signaling through activation of AMPK and inactivation of Akt, or via a TSC1/2-independent pathway through direct suppression of raptor. Our findings provide a molecular rationale whereby fenofibrate exerts anticancer and additional beneficial effects for the treatment of oral cancer patients.

Keywords :
Fenofibrate, Oral cancer, Warburg effect, Metabolic reprogramming, mTOR

Date Deposited : 04 Nov 2016 22:25

Last Modified : 04 Nov 2016 22:25

Official URL: http://www.ijbs.com/v12i7

Volume 12, Number 7, May 2016

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