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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2016 > Volume 12 Number 9 > Yankai Wen1,2, Seogsong Jeong1, Qiang Xia1, Xiaoni Kong1

Role of Osteopontin in Liver Diseases

Yankai Wen1,2, Seogsong Jeong1, Qiang Xia1, Xiaoni Kong1
1. Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; 2. School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.  Corresponding author: Xiaoni Kong, PhD., Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, China. 200127. Telephone: +862168383283; E-mail: xiaonikong@sjtu.edu.cn; xiaoni-kong@126.com or Qiang Xia, MD., E-mail: xiaqiang@medmail.com.cn
Abstract :

Osteopontin (OPN), a multifunctional protein, is involved in numerous pathological conditions including inflammation, immunity, angiogenesis, fibrogenesis and carcinogenesis in various tissues. Extensive studies have elucidated the critical role of OPN in cell signaling such as regulation of cell proliferation, migration, inflammation, fibrosis and tumor progression. In the liver, OPN interacts with integrins, CD44, vimentin and MyD88 signaling, thereby induces infiltration, migration, invasion and metastasis of cells. OPN is highlighted as a chemoattractant for macrophages and neutrophils during injury in inflammatory liver diseases. OPN activates hepatic stellate cells (HSCs) to exert an enhancer in fibrogenesis. The role of OPN in hepatocellular carcinoma (HCC) has also generated significant interests, especially with regards to its role as a diagnostic and prognostic factor. Interestingly, OPN acts an opposing role in liver repair under different pathological conditions. This review summarizes the current understanding of OPN in liver diseases. Further understanding of the pathophysiological role of OPN in cellular interactions and molecular mechanisms associated with hepatic inflammation, fibrosis and cancer may contribute to the development of novel strategies for clinical diagnosis, monitoring and therapy of liver diseases.

Keywords :
Osteopontin, liver injury, inflammation, fibrosis, hepatocellular carcinoma

Date Deposited : 07 Nov 2016 20:24

Last Modified : 07 Nov 2016 20:24

Official URL: http://www.ijbs.com/v12i9

Volume 12, Number 9, August 2016

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