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.: Home > Nature and Science > 2004 > Volume 2 Number 3 > Gláucio F. Diré 1 , Maria L. Gomes 1 , Elaine A. C. Lima 1 , R. L. Jales 3 , M. Castro Faria 1 , Mario Bernardo-Filho

Study of the Effects of Chayotte (Sechium Edule) Extracts on the Plasmid pUC. 9.1 DNA

Gláucio F. Diré 1 , Maria L. Gomes 1 , Elaine A. C. Lima 1 , R. L. Jales 3 , M. Castro Faria 1 , Mario Bernardo-Filho
(1. Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcantara Gomes, Departamento de Biofísica e Biometria; 2. Instituto Nacional do Câncer, Centro de Pesquisa Básica, Praça Cruz Vermelha; 3. Universidade Federal do Rio Grande do Norte, Departamento de Farmácia, Natal, Rio Grande do Norte, Brazil)
Abstract :

Stannous chloride (SnCl2) is employed as a reducing agent to obtain Technetium-99m-labelled
radiopharmaceuticals in nuclear medicine kits, being inject endovenously in humans. Toxic effects of these kits were  not  studied, thus making it important to evaluate their impact in  humans.  The  use of  natural extracts as medicines is  growing around the  world. The chayotte   (Sechium edule) is a  subtropical vegetable with potent diuretic action.  It is used in  folk medicine due its hypotensor effect. In this study, plasmid deoxyribonucleic acid (DNA) was exposed to chayotte extracts (macerated and decoct) (0.1 g.mL-1 ) in presence of stannous chloride (SnCl2). Samples of the plasmid DNA were analyzed through agarose gel electrophoresis. The  results show that the  chayotte extracts were capable of  damaging the DNA in the presence and in the absent of SnCl2. [Nature and Science. 2004;2(3):48-54].

Keywords :
plasmidial DNA, chayotte, nuclear medicine, stannous chloride.

Date Deposited : 11 Jan 2011 13:05

Last Modified : 12 Jan 2011 10:05

Official URL: http://www.sciencepub.org/nature/0101/

Volume 2, Number 3, October 2004 , ISSN 1545-0740

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