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.: Home > Nature and Science > 2011 > Volume 9 Number 2 > Heba Ez. Youssif, Mohamed Z. Mahran and Abeer A. Khedr

Hepatoprotective and antioxidant effects of Zizyphus spina-christi fruits on carbon tetrachloride induced hepatotoxicity in rats.

Heba Ez. Youssif, Mohamed Z. Mahran and Abeer A. Khedr
a Department of Nutrition and Food Sciences, Faculty of Home Economics, Menufyia University, Egypt.
Abstract :

In the present study the Zizyphus spina-christi fruits (ZSCF) (Nabk) as an antioxidant to protect against CCl4-induced oxidative stress and hepatotoxicity in Albino Wistar rats was investigated. Intraperitoneal injection of CCl4, administered twice a week, produced a marked elevation in the serum levels of aspartate transaminase, alanine transaminase, alkaline phosphatase and bilirubin. Daily dietary containing powder of (ZSCF) at 2.5%, 5%, 10%, and 15% of basal diet for 6 weeks produced a reduction in the serum levels of liver enzymes. Treatment with (ZSCF) normalized various biochemical parameters of oxidative stress. Furthermore, (ZSCF) has also restored normal levels of malondialdehyde and retained control activities of endogenous antioxidants such as SOD, and GSH. Therefore, the results of this study show that (ZSCF) can be protect the liver against CCl4-induce oxidative damage in rats, and the hepatoprotective effect can be correlated with its antioxidant and free radical scavenger effects.

Keywords :
Zizyphus spina-christi; CCL4, hepatotoxicty, rat, antioxidants-SOD, GSH and MAD

Date Deposited : 27 Jun 2011 09:32

Last Modified : 27 Jun 2011 09:32

Official URL: http://www.sciencepub.net/nature/ns0902/

Volume 9, Number 2, February 2011 , ISSN 1545-0740

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