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International Journal of Poultry Science

.: Home > International Journal of Poultry Science > 2010 > Volume 9 Number 7 > T. Srilatha1, V. Ravinder Reddy1, S. Qudratullah1 and M.V.L.N. Raju2

Effect of Alpha-lipoic Acid and Vitamin E in Diet on the Performance, Antioxidation and Immune Response in Broiler Chicken

T. Srilatha1, V. Ravinder Reddy1, S. Qudratullah1 and M.V.L.N. Raju2
1Department of Poultry Science, College of Veterinary Science, S.V.V.U. University, Rajendranagar, Hyderabad-5000 030, India 2Project Directorate on Poultry, ICAR, Rajendranagar, Hyderabad, India
Abstract :

An experiment was conducted to study the effects of alpha-lipoic acid at graded levels (0, 20, 40,
60, 80 mg/kg), Vit-E (10, 50 mg/kg) and their combination in a 5 x 2 factorial design on performance, antioxidation and immune response of broilers. 400 day-old male broilers were divided into 10 treatment groups, each with 8 replications (5 broilers in each) and fed one of the test diets till 6 weeks of age. Supplementation of Lipoic acid in broiler diet at 80 mg/kg gave significantly (p<0.05) higher BWG than control. The humoral immune response to NDV at 28 days age significantly (p<0.05) increased with lipoic acid at 20 and 80 mg/kg plus Vit-E 50 mg/kg. At 42 days age, HI titers were significantly (p<0.05) higher in all diets supplemented with lipoic acid than control. Cell mediated immunity was significantly (p<0.05) higher on diets that contained lipoic acid at 60 and 80 mg/kg than control. Similarly, Vit-E at 50 mg/kg also had significantly (p<0.05) higher CMI than Vit-E at 10 mg/kg. Supplementation of lipoic acid and vitamin E influenced the activities of lipid peroxidase. Inclusion of lipoic acid in all dietary treatment groups increased glutathione peroxidase levels. RBC catalase levels significantly (p<0.05) increased on diets that contained lipoic acid at 60 mg/kg. It is concluded that alpha - lipoic acid at 80 mg/kg and Vitamin E at 50 mg/kg may be supplemented to the broiler diet for improved growth, antioxidant status and better immune responses.

Keywords :
Alpha-Lipoic Acid (ALA), vitamin E, growth, antioxidation, immunity, broilers

Date Deposited : 27 Jun 2011 11:03

Last Modified : 27 Jun 2011 11:03

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Volume 9, Number 7, - 2010 , ISSN 1682-8356

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