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International Journal of Poultry Science

.: Home > International Journal of Poultry Science > 2010 > Volume 9 Number 11 > L.L. Hale-McWilliams , A.M. Cooksey 1 2, J.P. Thaxton1, L.M. Pinchuk2 and G.T. Pharr2

Proteomic Evaluation of Avian Peripheral Blood Monocytes for Functional Proteins

L.L. Hale-McWilliams , A.M. Cooksey 1 2, J.P. Thaxton1, L.M. Pinchuk2 and G.T. Pharr2
1Department of Poultry Science, Mississippi State University, Mississippi State, MS 39762, USA 2Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA
Abstract :

Monocytes as well as other professional Antigen Presenting Cells (APC), Dendritic Cells (DC) and
macrophages, play a critical role in adaptive and innate immune responses. A Differential Detergent
Fractionation (DDF) analysis was conducted on avian monocytes to reveal proteins related to cell adhesion, uptake and antigen presentation to lymphocytes, receptor proteins, proteases and cytokines. We identified a total of 3,229 proteins with 46 of these involved in the functions of professional APC. Of these proteins, fourteen were receptor proteins, four were related to antigen presentation (including MHC Class I), six to antigen uptake, ten to cell adhesion, two Toll-like receptors (TLR 4 and 15) and nine protease proteins were identified. This research demonstrates that the DDF approach provides meaningful, interpretable, functional, information concerning protein expression profiles associated with monocyte activation and differentiation into macrophages and/or immature DC in avian species. This data will be instrumental in future experiments evaluating protein expression of monocytes in stressed broilers.

Keywords :
Broiler, monocyte, functional proteins

Date Deposited : 28 Jun 2011 12:43

Last Modified : 28 Jun 2011 12:43

Official URL: http://www.pjbs.org/ijps/ijps.htm

Volume 9, Number 11, - 2010 , ISSN 1682-8356

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