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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2009 > Volume 58 Number 1 > SunBo SHIM1), SeHyun LEE1), ChuelKyu KIM1), ByoungGuk KIM1), SeungWan JEE1), SuHae LEE1), JiSoon SIN1), ChangJoon BAE1), Jong-Min WOO1), JungSik CHO2), EonPil LEE3), HaeWook CHOI3), HongSung KIM3), JaeHo LEE3), YoungJin JUNG3), ByungWooK CHO4), KabRyong CHAE1) and DaeYoun HWANG3)

Effects of Air Transportation Cause Physiological and Biochemical Changes Indicative of Stress Leading to Regulation of Chaperone Expression Levels and Corticosterone Concentration

SunBo SHIM1), SeHyun LEE1), ChuelKyu KIM1), ByoungGuk KIM1), SeungWan JEE1), SuHae LEE1), JiSoon SIN1), ChangJoon BAE1), Jong-Min WOO1), JungSik CHO2), EonPil LEE3), HaeWook CHOI3), HongSung KIM3), JaeHo LEE3), YoungJin JUNG3), ByungWooK CHO4), KabRyong CHAE1) and DaeYoun HWANG3)
1) Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA 2) Multidisciplinary Technology Institute, Hoseo University 3) Department of Biomaterial Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center 4) Department of Animal Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
Abstract :

Laboratory animals generally experience numerous unfamiliar environmental and psychological influences such as noises, temperatures, handling, shaking, and smells during the process of air transportation. To investigate whether stress induced by air transportation affects stress-related factors in animals, the levels of hormone and chaperone protein were measured in several tissues of F344 rats transported for 13 h and not transported. Herein, we conclude that the levels of corticosterone, HSP70, and GRP78 were significantly increased in the transported group compare to not transported group, but they were rapidly restored to the not transported group level after a recovery period of one week. However, the magnitude of induction and restoration levels of these factors varied depending on the tissue type. Thus, these results suggest that air transportation should be considered for the improvement of laboratory animal health and to reduce the incidence of laboratory animal stress.

Keywords :
air transportation, corticosterone, GRP78, HSP70, stress

Date Deposited : 04 Jul 2011 09:43

Last Modified : 04 Jul 2011 09:43

Official URL: http://www.jstage.jst.go.jp/article/expanim/

Volume 58, Number 1, - 2009 , ISSN 1881-7122

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