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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2009 > Volume 58 Number 1 > Tohru MIYATA1), Yuji MINAI2) and Minoru HAGA2)

Association of the Suckling-Weaning Transition with Development of the Hypothalamic Arcuate Nucleus Neurons in Rat Pups

Tohru MIYATA1), Yuji MINAI2) and Minoru HAGA2)
1) Departments of Bioresource Science, College of Agriculture, Tamagawa University 2) Departments of Life Science, College of Agriculture, Tamagawa University
Abstract :

 Feeding behavior is regulated by feeding-related peptides in the hypothalamus. The neurons of the arcuate nucleus (ARC), which produces feeding-related peptides, develop and function by three weeks of age in rodents. Because rodents are weaned at three weeks, we studied whether the process of weaning is involved in the development of ARC neurons using monosodium glutamate. Rat pups injected neonatally with monosodium glutamate ingested a large amount of mother's milk at weaning. Monosodium glutamate treatment induced a decrease in the number of ARC cells and mRNA levels of neuropeptide Y and agouti-related protein in the hypothalamus. The alteration of milk consumption following monosodium glutamate treatment appears to cause failure of ARC neuron development and neuropeptide expression.

Keywords :
arcuate nucleus neuron, feeding-related peptide, weaning

Date Deposited : 04 Jul 2011 10:03

Last Modified : 04 Jul 2011 10:03

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Volume 58, Number 1, - 2009 , ISSN 1881-7122

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