Animal Bioresource in Japan
.: Home > Animal Bioresource in Japan > 2009 > Volume 58 Number 1 > Masaru ICHIHASHI1), Hiromi TAKATANI1), Yoshikatsu HASHIMOTO2), Kouji YANO1), Atsuyuki NISHIDA1) and Kazuyuki KITAMURA1)
Effects of Nanpao®, a Kampo Medicine, on Peripheral Blood Flow and Surface Skin Temperature in Aged Female Rats
Masaru ICHIHASHI1), Hiromi TAKATANI1), Yoshikatsu HASHIMOTO2), Kouji YANO1), Atsuyuki NISHIDA1) and Kazuyuki KITAMURA1)
1) Safety Research Laboratory, Research Division, Mitsubishi Tanabe Pharma Corporation 2) Department of Pharmacology and Toxicology, Tanabe R&D Service Co., Ltd.
The effects of long-term treatment with Nanpao, a kampo medicine, on cold constitution were evaluated in aged female rats. Five-month-old rats were administered Nanpao orally at doses of 0, 30, or 100 mg/kg/day. The peripheral blood flow and surface skin temperature in the hind paws were measured using a laser Doppler blood flow meter and infrared thermography, respectively. In animals treated with Nanpao, the peripheral blood flow increased dose-dependently compared to that in the control group. Moreover, the surface skin temperature after immersion in ice-cold water was higher in the Nanpao-treated groups than in the control group at all measurement times. These results suggest that Nanpao has the potential to improve cold constitution associated with decreased peripheral blood flow in women.
cold constitution, kampo medicine, Nanpao
Date Deposited : 04 Jul 2011 10:06
Official URL: http://www.jstage.jst.go.jp/browse/expanim/_vols
Last Modified : 04 Jul 2011 10:06
Volume 58, Number 1, - 2009 , ISSN 1881-7122
Full Text Original