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International Journal of Medical Sciences

.: Home > International Journal of Medical Sciences > 2011 > Volume 8 Number 3 > Tamar A. Smith-Norowitz1,5 ƒx, Darrin Wong2, Melanie Kusonruksa2, Kevin B. Norowitz1,5, Rauno Joks3,5, Helen G. Durkin2,5, Martin H. Bluth4

Long Term Persistence of IgE Anti-Influenza Virus Antibodies in Pediatric and Adult Serum Post Vaccination with Influenza Virus Vaccine

Tamar A. Smith-Norowitz1,5 ƒx, Darrin Wong2, Melanie Kusonruksa2, Kevin B. Norowitz1,5, Rauno Joks3,5, Helen G. Durkin2,5, Martin H. Bluth4
1. Departments of Pediatrics, S.U.N.Y. Downstate Medical Center, Brooklyn, New York 11203, USA 2. Departments of Pathology, S.U.N.Y. Downstate Medical Center, Brooklyn, New York 11203, USA 3. Departments of Medicine, S.U.N.Y. Downstate Medical Center, Brooklyn, New York 11203, USA 4. Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA 5. Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, New York 11203, USA
Abstract :

The production of IgE specific to different viruses (HIV-1, Parvovirus B19, Parainfluenza virus, Varicella Zoster Virus), and the ability of IgE anti-HIV-1 to suppress HIV-1 production in vitro, strongly suggest an important role for IgE and/or anti viral specific IgE in viral pathogenesis. Nevertheless, the presence and persistence of IgE anti-Influenza virus antibodies has not been studied. Total serum IgE and specific IgE and IgG anti-Influenza virus antibodies were studied in children (N=3) (m/f 14-16 y/o) and adults (N=3) (m/f, 41-49 y/o) 2-20 months after vac-cination with Influenza virus (Flumist® or Fluzone®), as well as in non-vaccinated children (N=2). (UniCAP total IgE Fluoroenzymeimmunoassay, ELISA, Immunoblot). We found that serum of vaccinated children and adults contained IgE and IgG anti-Influenza virus antibodies approaching two years post vaccination. Non-vaccinated children did not make either IgE or IgG anti-Influenza antibodies. Similar levels of IL-2, IFN-م, IL-4, and IL-10 cytokines were detected in serum of vaccinated compared with non vaccinated subjects (p>0.05), as well as between vaccinated adults compared with vaccinated children and non vaccinated subjects (p>0.05). Vaccinated children and adults continue to produce IgE anti-Influenza virus anti-bodies long term post vaccination. The long term production of IgE anti-Influenza virus an-tibodies induced by vaccination may contribute to protective immunity against Influenza.

Keywords :
IgE, Influenza virus, Influenza virus vaccine

Date Deposited : 04 Jul 2011 11:01

Last Modified : 04 Jul 2011 11:01

Official URL: http://www.medsci.org/

Volume 8, Number 3, - 2011 , ISSN 1449-1907

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