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International Journal of Medical Sciences

.: Home > International Journal of Medical Sciences > 2011 > Volume 8 Number 4 > Sidney J. Stohs1, Harry G Preuss2ƒx, Samuel C. Keith3, Patti L. Keith3, Howard Miller4, Gilbert R. Kaats3

Effects of p-Synephrine alone and in Combination with Selected Bioflavo-noids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes

Sidney J. Stohs1, Harry G Preuss2ƒx, Samuel C. Keith3, Patti L. Keith3, Howard Miller4, Gilbert R. Kaats3
1. Dean Emeritus, Creighton University Health Sciences Center, Omaha, NE 68178, USA 2. Department of Physiology, Georgetown University Medical Center, Washington, DC, USA 3. Integrative Health Technologies, Inc., 4940 Broadway, San Antonio, TX 78209, USA 4. Nutratech Inc., West Caldwell, NJ 07006, USA
Abstract :

Bitter orange (Citrus aurantium) extract is widely used in dietary supplements for weight management and sports performance. Its primary protoalkaloid is p-synephrine. Most studies involving bitter orange extract and p-synephrine have used products with multiple ingredients. The current study assessed the thermogenic effects of p-synephrine alone and in conjunction with the flavonoids naringin and hesperidin in a double-blinded, randomized, place-bo-controlled protocol with 10 subjects per treatment group. Resting metabolic rates (RMR), blood pressure, heart rates and a self-reported rating scale were determined at baseline and 75 min after oral ingestion of the test products in V-8 juice. A decrease of 30 kcal occurred in the placebo control relative to baseline. The group receiving p-synephrine (50 mg) alone exhibited a 65 kcal increase in RMR as compared to the placebo group. The consumption of 600 mg naringin with 50 mg p-synephrine resulted in a 129 kcal increase in RMR relative to the placebo group. In the group receiving 100 mg hesperidin in addition to the 50 mg p-synephrine plus 600 mg naringin, the RMR increased by 183 kcal, an increase that was statistically sig-nificant with respect to the placebo control (p<0.02). However, consuming 1000 mg hes-peridin with 50 mg p-synephrine plus 600 mg naringin resulted in a RMR that was only 79 kcal greater than the placebo group. None of the treatment groups exhibited changes in heart rate or blood pressure relative to the control group, nor there were no differences in self-reported ratings of 10 symptoms between the treatment groups and the control group. This unusual finding of a thermogenic combination of ingredients that elevated metabolic rates without corresponding elevations in blood pressure and heart-rates warrants longer term studies to assess its value as a weight control agent.

Keywords :
p-Synephrine, naringin, hesperidin, resting metabolic rate, heart rate, blood pressure

Date Deposited : 04 Jul 2011 11:10

Last Modified : 04 Jul 2011 11:10

Official URL:

Volume 8, Number 4, - 2011 , ISSN 1449-1907

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