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International Journal of Medical Sciences

.: Home > International Journal of Medical Sciences > 2011 > Volume 8 Number 4 > Hong Zhang*, Qingmei Li*, Jie Sun, Chunyan Wang, Qing Gu, Xiangwei Feng, Bing Du, Wei Wang, Xiao-dong Shi, Siqi Zhang, Wanyu Li, Yanfang Jiang, Junyan Feng, Shumei Heƒx, Junqi Niu

Seroprevalence and Risk Factors for Hepatitis B Infection in an Adult Pop-ulation in Northeast China

Hong Zhang*, Qingmei Li*, Jie Sun, Chunyan Wang, Qing Gu, Xiangwei Feng, Bing Du, Wei Wang, Xiao-dong Shi, Siqi Zhang, Wanyu Li, Yanfang Jiang, Junyan Feng, Shumei Heƒx, Junqi Niu
Department of Hepatology, First Hospital, Jilin University, Changchun 130021, China
Abstract :

Background and aim: The prevalence of the hepatitis B virus (HBV) is higher in adults than in children. We determined the seroepidemiology of HBV infection in an adult population in JiLin, China, to guide effective preventive measures.
Methods: A cross-sectional serosurvey was conducted throughout JiLin, China. A total of 3833 people was selected and demographic and behavioral information gathered. Serum samples were tested for HBV markers and liver enzymes.
Results: The prevalence of the hepatitis B surface antigen (HBsAg), the antibody to the hepatitis B surface antigen (anti-HBs), the hepatitis B e antigen (HBeAg), the antibody to HBeAg (anti-HBe), and the antibody to the hepatitis B core antigen (anti-HBc) were 4.38%, 35.66%, 1.38%, 6.65%, and 40.88%, respectively. Alanine aminotransferase (ALT) and aspar-tate aminotransferase (AST) levels were significantly higher among HBsAg (+) than HBsAg (-) subjects. By multivariate logistic regression analysis, independent predictors for chronic HBV infection were smoking, poor sleep quality; occupation as private small-businessmen, laborers, or peasants; male gender; family history of HBV; personal history of vaccination; and older age. Independent predictors for exposure to HBV were large family size, occupation as a private small-businessman, male gender, family history of HBV, personal history of vaccina-tion, and older age. Independent predictors for immunity by vaccination were occupation as a private small-businessman, high income, personal history of vaccination, and young age. In-dependent predictors for immunity by exposure were drinking, male gender, personal history of vaccination, and older age.
Conclusions: The prevalence rate of HBV infection (4.38%) was lower than the previous rate of general HBV vaccination. However, 44.59% of the population remained susceptible to HBV. The prevalence of HBV infection was high in young adults, private small-businessmen, peasants, those with a family history of HBV, and males. Therefore, immunization of the non-immune population is reasonable to reduce hepatitis B transmission between adults.

Keywords :
hepatitis B; immunity; seroepidemiologic study; vaccine.

Date Deposited : 04 Jul 2011 11:17

Last Modified : 04 Jul 2011 11:17

Official URL: http://www.medsci.org/

Volume 8, Number 4, - 2011 , ISSN 1449-1907

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